Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 90-109 of 347
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Epidemiology, molecular characterization of hepatitis viruses in Rwanda and implication on liver disease
(2018-08-20)Hepatitis viruses cause major health problems worldwide and, according to WHO, is the seventh leading cause of death globally. It is primarily hepatitis B and C virus that causes chronic hepatitis, liver damage and fibrosis, ... -
Epigenetic regulation of oncogenes and tumor suppressors in chronic lymphocytic leukemia
(2017-10-26)DNA methylation is one of the well-known epigenetic modifications. Aberrant DNA methylation has been shown to have a major role in tumorigenesis and is associated with tumor aggressiveness and inferior outcome in various ... -
Epigenetics of paediatric glioma stem cells; focusing on exosomes, miRNAs and DNA methylation
(2019-03-14)Tumours in the central nervous system are accountable for the majority of cancer-related deaths in children. Glioblastoma multiforme, one of the deadliest of the central nervous system tumours, is partly driven by glioma ... -
The Epstein-Barr Virus Nuclear Antigens 1 and 5; Study of virus-host cellular protein interactions
(2009-11-22)The Epstein-Barr virus (EBV) is the causative agent or cofactor in the aetiology of several human malignancies such as Burkitt’s lymphoma, Hodgkin’s disease, nasopharyngeal carcinoma (NPC) and lymphoproliferative disorder ... -
Evaluation of fucosylated receptors for Cholera toxin in the human small intestine
(2019-10-22)Cholera toxin (CT) produced by Vibrio cholerae is the causative agent for the diarrheal disease cholera. Cholera is yearly afflicting millions and is estimated to kill over 100 000 people every year. In this thesis I aimed ... -
Evolution of human alpha-herpesviruses
(2007-04-24)Herpesviridae is a large virus family with more than 100 members, which are highly disseminated among animals. Three sub-families have been classified; alpha-herpesviruses, beta-herpesviruses and gamma-herpesviruses. Eight ... -
Evolution of protein and non-coding RNA genes studied with comparative genomics
(2010-12-16)The identification of protein and non-coding RNA (ncRNA) genes is one important step in the analysis of a genome. This thesis focuses on the identification and analysis of proteins and ncRNAs homologues by exploiting a ... -
Evolution of Transmembrane and Gel-forming Mucins Studied with Bioinformatic Methods
(2007-11-13)All mucosal membranes of the body are covered by mucus, largely made up of the family of large glycoproteins called mucins. These are instrumental for the protection of the underlying epithelia and involved in the pathogenesis ... -
Experiencing life as migrants living with HIV in Sweden
(2019-11-27)The focus of this thesis is on the life situation of migrants living with HIV in Sweden. The overall aim of this thesis was to explore the knowledge of HIV-positive migrants’ life situation in Sweden, with a focus on health ... -
Exploring novel therapeutic strategies in neuroblastoma
(2020-10-29)Neuroblastoma (NB) is the most frequently diagnosed extracranial tumour in children, which arises from transient embryonal tissue of the neural crest that fails to complete terminal differentiation into neurons. Even after ... -
Exploring the heterogeneity of the hematopoietic stem and progenitor cell pool in cord blood
(2017-10-17)Hematopoietic stem cell transplantation (HSCT) is a curative treatment for a wide range of malignant and hereditary disorders. It is yet the only clinically established stem cell treatment. Hematopoietic stem and progenitor ... -
Expression profiling of Gastrointestinal Stromal Tumors - Biomarkers for Prognosis and Therapy
(2013-04-17)Gastrointestinal stromal tumor (GIST) is a mesenchymal tumor of the gastrointestinal tract with a clinical spectrum ranging from indolent tumors to tumors with aggressive behavior and poor patient survival. The established ... -
The female genital tract microbiota: composition, relation to innate immune factors, and effects of contraceptives
(2009-05-13)Abnormal vaginal microbiota, as in bacterial vaginosis (BV), is associated with increased risk of obstetrical and gynaecologic complications and acquisition of sexually transmitted diseases. However, very little is known ... -
FET fusion oncoproteins in sarcoma tumorigenesis - lnteractions with the SWI/SNF chromatin remodeling complex and epigenetic effects
(2021-11-23)The FET family of fusion oncoproteins containing the N-terminal of either FUS, EWSR1 or TAF15 together with a transcription factor partner is the characteristic oncogenic driver of more than 20 types of sarcoma and leukemia, ... -
FET proteins in cancer and development
(2009-02-13)Chromosomal translocations leading to rearrangements of FET family genes (FUS, EWSR1 and TAF15) are found in numerous human cancers. These genetic alterations result in the formation of fusion oncogenes that express potent ... -
Filamin A in Cardiovascular Remodeling
(2018-11-12)Filamin A (FLNA) is a large actin-binding cytoskeletal protein that stabilizes actin networks and integrates them with cell membranes. FLNA is therefore important for cell motility and organ development. We recently ... -
Fluoroquinolone resistance in the environment and the human gut – Analysis of bacterial DNA sequences to explore the underlying genetic mechanisms
(2014-04-04)Fluoroquinolones (FQs) are synthetic, broad-spectrum antibiotics that target type II topoisomerases. High-level resistance is often caused by mutations in the target genes of FQs, especially in gyrA and parC. In contrast, ... -
Forkhead genes in adipocytes and podocytes
(2016-10-27)Forkhead genes are a family of transcription factors with important functions in development and metabolism. This thesis addresses tissue-specific functions of the two forkhead genes, FOXC2 and FOXF2, using transgenic mouse ... -
Foxf2 and Foxc2, two transcription factors that regulate adipocyte metabolism
(2010-05-28)Type 2 diabetes is the most common metabolic disorder today and has reached epidemic proportions in many countries. Diet-induced insulin resistance plays a central role in the development of type 2 diabetes. Studies included ... -
Foxi1, an important gene for hearing, kidney function and male fertility
(2007-08-27)Aim: In this study we focused on the biological importance of the forkhead transcription factor Foxi1. The overall aim was to elucidate the functional role of Foxi1 in the inner ear, kidney and epididymis. When mice ...