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Filamin A in Cardiovascular Remodeling


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Title: Filamin A in Cardiovascular Remodeling
Authors: Bandaru, Sashidhar
E-mail: sashidar.bandaru@medkem.gu.se
Issue Date: 12-Nov-2018
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Biochemistry and Cell Biology
Parts of work: I. Deficiency of filamin A in endothelial cells impairs left ventricular remodelling after myocardial infarction. Bandaru S, Grönros J, Redfors B, Çil Ç, Pazooki D, Salimi R, Larsson E, Zhou AX, Ömerovic E, Akyürek LM. Cardiovasc Res. 2015 Feb 1;105(2):151-9.
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II. Targeting filamin A reduces macrophage activity and atherosclerosis in mice. Bandaru S, Salimi R, Ala C, Akula MK, Ekstrand M, Devarakonda S, Karlsson J, Levin M, Borén J, Bergo MO, Akyürek LM. (Manuscript)
Date of Defence: 2018-11-29
Disputation: Torsdagen den 29 september, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg.
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Filamin A
Cardiovascular remodelling
Abstract: Filamin A (FLNA) is a large actin-binding cytoskeletal protein that stabilizes actin networks and integrates them with cell membranes. FLNA is therefore important for cell motility and organ development. We recently discovered that a C-terminal fragment of FLNA (FLNACT) can be cleaved off by calpain and stimulate angiogenesis by transporting transcription factors into the nucleus. However, little is known about the role of FLNA in cell types that participate in the pathogenesis of vascular disea... more
ISBN: 978-91-7833-229-8
978-91-7833-230-4
URI: http://hdl.handle.net/2077/56922
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

 

 

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