Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 327-346 of 347
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Towards restoring intestinal health after pelvic radiotherapy - Lessons from dietary fiber intervention in a novel mouse model
(2019-11-18)Patients who have cancer in the pelvic region are at risk of developing gastrointestinal symptoms for weeks, months, or even years after receiving radiotherapy. These symptoms are triggered due to unwanted radiation-induced ... -
Trafficking of Human Dendritic Cells and B cells in Helicobacter pylori-induced Gastritis
(2009-11-13)Infection with the bacterium Helicobacter pylori is widespread throughout the world, and is associated with development of gastric and duodenal ulcer disease as well as gastric adenocarcinoma and mucosa associated lymphoid ... -
Transcriptional profiling of human embryonic stem cells and their functional derivatives
(2010-10-07)Human embryonic stem cells (hESCs) represent populations of pluripotent, undifferentiated cells with unlimited replication capacity, and with the ability to differentiate into any functional cell type in the human body. ... -
Transcriptional Regulation of the Platelet-Derived Growth Factor B-receptor by p53 Family Members
(2008-09-29)Aims: The platelet-derived growth factor β-receptor (PDGFRB) is critically involved in embryonic development and has a role in many diseases. In cells, signaling through PDGFRB affects growth, migration and death. The role ... -
Transcriptional regulation of thyroid development possible interplay of endoderm- and mesoderm-derived morphogenetic signals
(2008-10-14)Congenital hypothyroidism (CH) affects 1 in 3000 children and is the major cause of treatable mental retardation. Most cases are due to malformations of the gland, collectively named thyroid dysgenesis. The disease results ... -
Transcriptomic and functional studies of fusion oncogene-driven salivary gland tumors
(2020-11-25)Fusion genes are potent oncogenic drivers resulting from exchange of regulatory/coding sequences between two genes. They were originally identified in leukemias but are now recognized as key oncogenic events also in many ... -
The transcriptomic landscape of Epstein-Barr virus associated tumors at cellular and single-molecule level
(2022-06-10)Epstein-Barr virus (EBV) was the first oncovirus found in humans. Almost all adults worldwide are asymptomatic carriers of EBV. The latent EBV-infection malignifies in approximately 200,000 individuals each year. The risk ... -
Tumor cell heterogeneity profiling using single-cell analysis
(2020-02-13)Cancer is a diverse disease with large variations between tumor types and patients regarding tumor progression and prognosis. Additionally, most individual tumors are heterogeneous, containing subpopulations of cells with ... -
Two new disorders of glycogen metabolism
(2014-01-08)Glycogen is a polymer of glucose and serves as a source of rapidly available energy. Glycogen synthesis is initiated by autoglucosylation of glycogenin. Two glycogenin genes, GYG1 and GYG2, encode the two isoforms glycogenin-1 ... -
Ultrasensitive DNA sequencing using liquid biopsies enables precision medicine
(2021-03-18)Liquid biopsies are minimally invasive and allow repetitive sampling of body fluids. Analysis of cell-free tumor DNA in liquid biopsies can be used as a biomarker for cancer. However, in most clinically relevant liquid ... -
Unconventional T cells in colon adenocarcinomas
(2023-05-05)Many factors influence the initiation and growth of tumours. The infiltration and activity of immune cells in the tumour microenvironment are widely recognised as key factors affecting the clinical outcome of cancer. In ... -
Understanding the regulatory requirements for gut IgA B cell responses and their potential role in mucosal vaccine development
(2018-05-28)It is important to understand gut B cell differentiation, from the activation of cells at inductive lymphoid sites to the formation of gut plasma and memory B cell, to be able to develop efficient oral vaccines but the ... -
Understanding the role of long non-coding RNAs in neuroblastoma development and progression
(2019-11-11)Neuroblastoma (NB), a common cancer of childhood, contributes to 15% of all pediatric cancer deaths. The improper neuronal differentiation of neural crest cells to mature neurons in the sympathetic nervous system leads to ... -
Understanding the role of the Parkinson’s associated kinase LRRK2 in inflammation and infection
(2024-01-16)The innate immune system, which mediates pathogen clearance and tissue healing, requires tight regulation to avert self-destruction. The endo-lysosomal system is best known as a network of vesicles that targets particles ... -
Unravelling the mechanisms for mucosal tolerance induction using the CTA1R7K-X-DD immunomodulating fusion protein
(2016-11-11)Unravelling the mechanisms for mucosal tolerance induction using the CTA1R7K-X-DD immunomodulating fusion protein: Effective treatment options against autoimmune diseases Tolerance is a physiological mechanism that ... -
Vaccination against cholera and ETEC diarrhea and interventions to improve vaccine immune responses.
(2009-06-10)Vaccination against cholera and ETEC diarrhea and interventions to improve vaccine immune responses Abstract Vibrio cholerae O1 and enterotoxigenic Escherichia coli (ETEC) together account for the majority of bacterial ... -
Vaginal commensal bacteria. Interactions with cervix epithelial and monocytic cells and influence on cytokines and secretory leukocyte protease inhibitor, SLPI
(2008-11-14)Vaginal commensal bacteria Interactions with cervix epithelial and monocytic cells and influence on cytokines and secretory leukocyte protease inhibitor, SLPI Louise Strömbeck Department of Infectious Medicine, ... -
Varicella-zoster virus infections of the central nervous system
(2013-05-24)Both varicella (chickenpox), and the reactivated form of herpes zoster (shingles), may cause neurological complications with various central nervous system (CNS) manifestations. Following introduction of PCR as a diagnostic ... -
Viral proteins as serological antigens - Development and clinical applications
(2022-05-24)Serological methods are based on the detection of antibodies and antigens in mainly serum but also in other body fluids such as cerebrospinal fluid (CSF). Conventional whole virus antigens are widely used in viral serological ... -
Virulence factors and clonal relatedness of enterotoxigenic Escherichia coli (ETEC) isolated from children with diarrhoea in Bolivia
(2011-11-25)Enterotoxigenic Escherichia coli (ETEC) is one of the major causes of diarrhoea in children under five years of age in developing countries and in travellers to these settings. To cause disease, ETEC must be able to colonize ...