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Vaccination against cholera and ETEC diarrhea and interventions to improve vaccine immune responses.

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Title: Vaccination against cholera and ETEC diarrhea and interventions to improve vaccine immune responses.
Authors: Ahmed, Tanvir
Issue Date: 10-Jun-2009
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Microbiology and Immunology
Parts of work: I. Qadri F, Ahmed T, Ahmed F, Begum YA, Sack DA and Svennerholm AM: Reduced doses of oral killed enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine is safe and immunogenic in Bangladeshi infants 6–17 months of age: Dosing studies in different age groups. Vaccine 24, 1726-33, 2006.

II. Qadri F, Ahmed T, Ahmed F, Bhuiyan MS, Mostofa MG, Cassels FJ, Helander A and Svennerholm AM: Mucosal and systemic immune responses in patients with diarrhea due to CS6-expressing enterotoxigenic Escherichia coli. Infect Immun 75, 2269-74, 2007.

III. Ahmed T, Lundgren A, Arifuzzaman M, Qadri F, Teneberg S, Svennerholm AM: Children with Lewis (a+b-) blood group have increased susceptibility to diarrhea caused by enterotoxigenic Escherichia coli expressing colonization factor I-group fimbriae. Infect Immun 77, 2059-2064, 2009.

IV. Ahmed T, Svennerholm AM, Tarique AA, Sultana GN and Qadri F: Enhanced immunogenicity of an oral inactivated cholera vaccine in infants in Bangladesh obtained by zinc supplementation and by temporary withholding breast feeding. Vaccine 27, 1433-1439, 2009.

V. Ahmed T, Arifuzzaman M, Lebens M, Qadri F, Lundgren A: CD4+ T-cell responses to an oral inactivated cholera vaccine in young children in a cholera endemic country and the enhancing effect of zinc supplementation. Submitted for publication.
Date of Defence: 2009-06-02
Disputation: Tisdag den 2 juni 2009, kl. 9.00, Hörsal Ragnar Sandberg, Medicinaregatan 7A, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Vibrio cholerae
oral vaccine
Lewis blood group
breast feeding
T cell
B cell
Abstract: Vaccination against cholera and ETEC diarrhea and interventions to improve vaccine immune responses Abstract Vibrio cholerae O1 and enterotoxigenic Escherichia coli (ETEC) together account for the majority of bacterial causes of acute dehydrating diarrhea in children in Bangladesh. Vaccines should be considered as an important public health tool for prevention of these diarrheal diseases. However, a limitation for the use of vaccines in developing countries is that the efficacy and immunogeni... more
ISBN: 978-91-628-7789-7
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet



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