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Understanding the regulatory requirements for gut IgA B cell responses and their potential role in mucosal vaccine development

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Title: Understanding the regulatory requirements for gut IgA B cell responses and their potential role in mucosal vaccine development
Authors: Komban, Rathan Joy
Issue Date: 28-May-2018
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Microbiology and Immunology
Parts of work: I. Komban R., Strömberg A., Jakob Cervin., Cervin J., Yrlid U., Johannes Mayer, Simon Milling., Mats Bemark., and Nils Lycke. Orally activated B cells migrate via lymph to multiple Peyer’s patches where they re-utilize germinal centres in an antigen and CD40-dependent fashion. Manuscript, 2018.

II. Komban R., Strömberg A., Biram A., Cervin J., Yrlid U., Shulman Z., Bemark M., and Lycke N. Activated Peyer’s patch B cells sample antigen from M cells in the sub epithelial dome to maintain gut germinal center responses. Manuscript under revision in Nature Communications.

III. Bemark M, Hazanov H, Strömberg A, Komban R, Holmqvist J, Koster S, et al. Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization. Nat Commun 2016, 7: 12698.

IV. Komban R., Bergqvist B., Strömberg A., Bemark M., and Lycke N. Germ free mice exhibit poor gut IgA plasma cells responses but host intact and effective inductive sites in their Peyer´s patches. Manuscript.
Date of Defence: 2018-06-14
Disputation: Torsdagen den 14 juni 2018, kl. 09:00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Germinal centers
IgA B cell
Germ free mice
Sub-epithelial dome
Abstract: It is important to understand gut B cell differentiation, from the activation of cells at inductive lymphoid sites to the formation of gut plasma and memory B cell, to be able to develop efficient oral vaccines but the process is incompletely defined. To address this we developed an adoptive transfer system based on B1-8hi/GFP+ NP-specific B cells and NP-CT, a hapten-carrier complex that allows us to follow antigen-specific IgA responses following oral immunization. In paper (Ι) we provide evid... more
ISBN: 978-91-7833-030-0 (PDF)
978-91-7833-029-4 (TRYCK)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin



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