Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 247-266 of 347
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On the assessment and impact of liver fibrosis in patients with chronic hepatitis C
(2013-11-22)Hepatitis C virus (HCV) infection is associated with increased risk of severe liver damage, cirrhosis, and hepatocellular carcinoma (HCC). Despite pending highly efficacious HCV treatment, assessment of liver damage will ... -
On the Diagnosis and Management of Viral Respiratory Infections
(2010-05-28)Acute respiratory tract infections (ARTIs), are the most common infections in man, and represent a major global health burden. Viruses, most often causing a mild and self-limiting disease, yet with substantial morbidity ... -
On the epidemiology, clinical presentation and transmission of respiratory viral infections
(2020-03-05)Respiratory viral infections encompass a large heterogenous group of pathogens that constitute a major burden of disease globally. The various routes of transmission including airborne spread make them difficult to control. ... -
On the Origins of mobile Antibiotic Resistance Genes
(2021-05-17)Mobile antibiotic resistance genes (ARGs), transferable between bacterial cells, are major contributors to the antibiotic resistance crisis we are facing today. From which organisms pathogens acquired these genes is ... -
On the outcome of antiviral therapy for hepatitis C virus genotype 2 or 3 infection
(2011-11-09)Abstract Approximately 80% of patients infected with HCV genotypes 2 or 3 achieve a sustained virological response (SVR), following 24 weeks of therapy with ribavirin and pegylated interferon (peg-IFN), but in light of ... -
On the role of genetic variation and epigenetics in hemostatic gene regulation
(2020-01-17)Many genetic variants have been identified to associate with circulating levels of hemostatic proteins and with thrombotic or hemorrhagic disorders. However, the underlying molecular mechanisms remain largely unknown. ... -
On the role of innate cell interactions in inflammation and leukemia
(2015-05-18)Inflammatory cells of the innate immune system launch rapid and powerful effector responses in the combat against infectious pathogens. However, these inflammatory mediators may cause excessive damage to the host and, ... -
On the role of Natural Killer cell immunogenetics for the outcome of immunotherapy in acute myeloid leukemia
(2022-02-14)Numerous studies have revealed that natural killer cells have fundamental roles as effector cells in myeloid leukemias. Thus, understanding NK cell-related biomarkers that influence clinical outcome are warranted. This ... -
On the role of signaling pathways in the pathogenesis of osteoarthritis
(2014-04-15)The problem with degenerating cartilage tissues is one of the major causes for disability worldwide. The aetiology of the cartilage degenerating disease osteoarthritis is elusive and considered to be multifactorial. The ... -
On the stimulatory effect of microglial cells on angiogenesis
(2011-05-26)ABSTRACT Angiogenesis, the process by which new vessels sprout from pre-existing vessels, is fundamental to development, tissue growth and repair. The main aim of this thesis was to investigate the role of microglia on ... -
Oncogenic ALK signaling in neuroblastoma
(2017-05-15)Over the last decade Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase (RTK) has been identified as a translocation partner in diverse cancer types. In tumors, where the full-length ALK RTK itself is mutated, ... -
Origins of thyroid progenitors and tumor-initiating cells
(2018-05-14)The thyroid gland located in the anterior neck consists of two main cell types. First, the follicular cells that form the functional units, the follicles, in which thyroid hormones are produced and stored before release ... -
Oxidant-induced cell death in lymphocytes: mechanisms of induction and resistance
(2007-04-16)Reactive oxygen species (oxidants, oxygen radicals) produced by the phagocytic NADPH oxidase have pivotal roles in immunity. Patients lacking a functional NADPH oxidase suffer from chronic granulomatous disease, which is ... -
Pan-cancer study of transcriptional responses to oncogenic somatic mutations
(2021-05-27)Cancer cells typically carry acquired somatic mutations in key cancer driver genes, which can be identified on the basis of recurrence in cancer cohorts. Such mutations may cause aberrant protein activity and altered gene ... -
Pathogenic mechanisms affecting mitochondrial DNA replication and transcription
(2023-04-24)Mitochondria are cytoplasmic organelles fundamental to life and health. In mitochondria, energy from the food we eat is converted into adenosine triphosphate (ATP), which in turn is used as a source of chemical energy to ... -
Pathophysiological impact of targeting the ROS-p53 axis
(2014-10-21)The goal of this PhD thesis was to define the importance of the interplay between reactive oxygen species (ROS) and their activation of the tumor suppressor p53 in development and disease. We addressed this question using ... -
Patient-derived scaffolds as a 3D model for breast cancer
(2023-02-17)Breast cancer is the most common cancer form in women worldwide. Many patients will have recurrent disease and more efficient targeted therapies are needed. The tumor microenvironment is a heterogenous complex mix of cells ... -
Perspectives on urban wastewater as a source of microbial pollution
(2020-01-17)Wastewater treatment plants are important links for dissemination of intestinal bacteria into surface waters. In this study, twelve mallards were exposed to treated wastewater for a period of 55 days. Faecal samples were ... -
Presence and viability of enterotoxigenic Escherichia coli (ETEC) in aquatic environments
(2009-12-07)Enterotoxigenic Escherichia coli (ETEC) is one of the major causes of diarrhoea among children in developing countries and in travelers to these regions. The bacteria are spread via contaminated water and food, and surface ... -
Profiling of Small Intestine Neuroendocrine Tumors
(2014-11-04)Small intestine neuroendocrine tumors (SI-NETs) are malignant neoplasms usually presenting with disseminated disease and symptoms of hormone overproduction. Radical surgery is curative but can only be performed for localized ...