Browsing Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin by Title
Now showing items 205-224 of 347
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Molecular analysis of the FET family fusion oncoprotein FUS-DDIT3
(2012-12-20)Chromosomal translocations leading to formation of tumor type specific fusion oncogenes are frequently found in human cancers. The FET family genes (FUS, EWSR1 and TAF15) occur in translocations with genes encoding various ... -
Molecular and genetic studies in high-risk neuroblastoma
(2021-02-04)Neuroblastoma is the most common and deadly cancer in the first year of life. Children with high-risk neuroblastoma have a very poor prognosis, despite heavy multimodal treatment, with less than 50% of 5 years of overall ... -
Molecular and genetic studies of DLG2 in neuroblastoma and colorectal cancer
(2022-05-19)Neuroblastoma is one of the most common extra cranial solid tumors in children. It is one of the most common causes of death amongst the pediatric malignancies. There is however a large difference between the low risk ... -
Molecular and structural studies of proteins required for mitochondrial DNA maintenance
(2022-04-28)Mitochondria are membrane-bound organelles that produce the majority of ATP used to drive metabolic processes in eukaryotic cells. A unique feature of mitochondria is the existence of a separate mitochondrial DNA (mtDNA), ... -
Molecular aspects on Herpes simplex virus type 1 DNA replication and gene expression
(2017-12-22)Herpesviruses infect a variety of animals from molluscs to humans and they have evolved in a close relationship with their hosts. In humans, we find nine herpesviruses, representing all three subfamilies of the family ... -
Molecular biosignatures and gut-barrier alterations in inflammatory bowel diseases
(2022-08-23)Inflammatory bowel diseases (IBD) are chronic immune-mediated disorders affecting the gastrointestinal tract. The multifactorial pathophysiology of IBD is commonly explained as an abnormal interplay between genetic, immune, ... -
Molecular characterization of neuroblastoma tumors - a basis for personalized medicine.
(2012-05-24)Neuroblastoma is a very heterogeneous tumor, with a clinical course ranging from spontaneous regression to aggressive tumor growth. A proper stratification of the patients into different risk groups is therefore important ... -
Molecular factors influencing epithelial-mesenchymal transition in breast cancer
(2014-08-22)Epithelial-mesenchymal transition (EMT) is a developmental process defined by loss of epithelial characteristics and acquisition of mesenchymal phenotype. EMT or similar processes are also implicated in carcinoma cell ... -
Molecular insights into mitochondrial transcription and its role in DNA replication
(2016-12-07)The mitochondrion is an organelle of the eukaryotic cell responsible for the production of most of the cellular energy-carrying molecule adenosine triphosphate (ATP), through the process of oxidative phosphorylation. The ... -
Molecular insights into primer removal during mtDNA replication
(2021-03-01)Mitochondria are vital for cell survival, and the primary producers of ATP, the energy currency used for various metabolic processes. Mitochondria are unique from other cellular compartments ... -
Molecular mechanisms for lineage-restricted differentiation of adult neural progenitors
(2008-05-21)Aims: In the central nervous system of several species, including humans, neurogenesis per¬sists even in the adult life in discrete neurogenic regions of the brain. Adult neural stem cells derived from these neurogenic ... -
Molecular mechanisms of embryonic stem cell pluripotency: transcription, telomere maintenance and proliferation
(2010-11-19)Somatic cell nuclear transfer and generation of induced pluripotent stem cells provide potential routes towards generation of patient specific embryonic stem (ES) cells. These procedures require induction of Oct4 gene ... -
Molecular mechanisms of human presynapse assembly - role of liprin-alpha proteins in synapse organization and neurological disease
(2024-04-18)Synapses are the essential transmission units of neuronal circuits and represent the cornerstone of our unique cognitive abilities. During synapse formation, contact between two neurons induce the assembly of pre- and ... -
Molecular regulation of epithelial tube size
(2009-02-27)In nature, epithelial tubes are vital structures in organ design and are required for transport of gases and liquids in organs, such as the vascular system, the vertebrate lung and the kidneys. The tubular epithelium is ... -
Monoclonal antibodies against human papillomavirus E7 oncoprotein for diagnosis of cervical neoplasia and cancer
(2012-10-08)Cervical cancer is the second most common cancer among women worldwide with half a million of new cases every year. Cervical cancer is caused by oncogenic human papillomaviruses (HPVs), with HPV16 and 18 being the most ... -
A mouse model for direct evaluation of cholera vaccines
(2009-04-23)Cholera continues to be an important cause of morbidity and mortality in large parts of the developing world and is a significant negative factor for economic development. Vibrio cholerae bacteria of the O1 or O139 serogroup ... -
The MUC2 mucin -A network in the intestinal protective mucus
(2009-05-26)The intestine is covered by mucus that is the first line of defence of the epithelium. The main structural component of the intestinal mucus is the MUC2 mucin. This is a large glycoprotein with two long and heavily ... -
Mucin-like proteins in Drosophila development
(2014-01-17)Mucins are large and highly glycosylated proteins and major component of the mucus that coats the lining of epithelial organs. Mucins are characterized by the presence of extended regions rich in the amino acids Proline, ... -
Mucosal adjuvants and their mode of action in the female genital tract
(2010-10-18)Sexually transmitted infections (STIs) cause a socioeconomic burden, morbidity and even mortality in a large part of the human population all over the world today. One of the most common genital ulcerative diseases is ... -
Mucus and mucins during gastrointestinal infections
(2014-03-24)The gastrointestinal tract is protected by a continuously secreted mucus layer formed by mucin glycoproteins. The mucus layer and mucins change dynamically during infection. The main focus of this thesis was to investigate ...