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Monoclonal antibodies against human papillomavirus E7 oncoprotein for diagnosis of cervical neoplasia and cancer


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Title: Monoclonal antibodies against human papillomavirus E7 oncoprotein for diagnosis of cervical neoplasia and cancer
Authors: Lidqvist, Maria
E-mail: maria.lidqvist@fdab.com
Issue Date: 8-Oct-2012
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Microbiology and Immunology
Parts of work: I. Maria Lidqvist, Olle Nilsson, Jan Holmgren, Christina Hall, Christian Fermér. Phage display for site-specific immunization and characterization of high-risk human papillomavirus specific E7 monoclonal antibodies. Journal of Immunological Methods, 337 (2008) 88-96.
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II. Maria Lidqvist, Olle Nilsson, Jan Holmgren, Sebastian Hölters, Eva Röijer, Matthias Dürst, Christian Fermér. Detection of human papillomavirus oncoprotein E7 in liquid-based cytology. Journal of General Virology, 93 (2012) 356–363.
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III. Michael Lebens, Susanne Källgård, Christian Fermer, Maria Lidqvist, Hubert Bernauer. Generation of plasmid encoded protein-specific overlapping peptide libraries and the mapping of B cell epitopes in HPV E7 oncoprotein recognized by monoclonal antibodies and antibodies in the serum of immunized mice. Submitted manuscript.

IV. Maria Lidqvist, Olle Nilsson, Jan Holmgren, Matthias Dürst, Elin Andersson, Peter Horal, Christian Fermér. Clinical feasibility study of anti-E7 MAb for detection of HPV-induced neoplasia and cancer in liquid-based cytology. Submitted manuscript.
Date of Defence: 2012-10-26
Disputation: Fredagen den 26 oktober 2012, kl. 13:00, Hörsal Arvid Carlsson, Acedemicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Human papillomavirus (HPV)
Cervical cancer
Cervical neoplasia
E7 oncoprotein
Monoclonal antibodies
Cytology
Immunocytochemistry
Phage display
Abstract: Cervical cancer is the second most common cancer among women worldwide with half a million of new cases every year. Cervical cancer is caused by oncogenic human papillomaviruses (HPVs), with HPV16 and 18 being the most frequently detected types. Genital HPV infections are common in the general population although most infections are cleared before causing malignancy. However a small proportion of the infections evade the immune system, become persistent and may cause cervical lesions and even in... more
ISBN: 978-91-628-8511-3
URI: http://hdl.handle.net/2077/29710
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

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