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Physiological role of amyloid precursor protein during neural development

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Title: Physiological role of amyloid precursor protein during neural development
Authors: Banote, Rakesh Kumar
Issue Date: 22-May-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry
Parts of work: Abramsson A, Kettunen P, Banote RK, Lott E, Li M, Arner A, Zetterberg H. The zebrafish amyloid precursor protein-b is required for motor neuron guidance and synapse formation. Dev Biol. 2013; 15;381(2):377-88.

Banote RK, Edling M, Eliassen F, Kettunen P, Zetterberg H, Abramsson A. β-Amyloid precursor protein-b is essential for Mauthner cell development in the zebrafish in a Notch-dependent manner. Dev Biol. 2016; 1;413(1):26-38.

Banote RK, Edling M, Şatır TM, Burgess SM, Chebli J, Abramsson A, Zetterberg H. Characterization of β-amyloid precursor protein-b zebrafish mutants during early development. Manuscript

Abramsson A, Banote RK, Gobom J, Hansson KT, Blennow K, Zetterberg H. Quantitative proteomics analysis of amyloid precursor protein hypomorphic zebrafish (Danio rerio) embryos using TMT 10-plex isobaric labeling. Manuscript
Date of Defence: 2017-06-16
Disputation: Fredagen den 16 juni 2017, kl. 9.00, Hjärtats Aula, Blå stråket 5, Sahlgrenska Universitetssjukhuset, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Amyloid precursor protein
Spinal cord
Motor neurons
Mauthner cell
Abstract: Amyloid precursor protein (APP) is a type-one membrane-spanning protein with a large extracellular N-terminal domain and a small intracellular C-terminal domain. APP first gained interest due to its involvement in the pathogenesis of Alzheimer’s disease (AD). Its proteolytic processing liberates the neurotoxic amyloid-beta (Aβ) peptide that accumulates in the amyloid plaques, characteristic of AD. Thus, APP has been intensively studied for its amyloidogenic properties with less focus on its... more
ISBN: 978-91-629-0212-4 (PRINT)
978-91-629-0211-7 (PDF)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi



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