GUPEA >
Sahlgrenska Academy / Sahlgrenska akademin >
Institute of Neuroscience and Physiology / Inst för neurovetenskap och fysiologi >
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi >

Physiological role of amyloid precursor protein during neural development


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/51893

Files in This Item:

File Description SizeFormat
gupea_2077_51893_1.pdfThesis frame5747KbAdobe PDF
View/Open
gupea_2077_51893_2.pdfCover1463KbAdobe PDF
View/Open
gupea_2077_51893_3.pdfAbstract212KbAdobe PDF
View/Open
Title: Physiological role of amyloid precursor protein during neural development
Authors: Banote, Rakesh Kumar
E-mail: rakesh.k.banote@neuro.gu.se
Issue Date: 22-May-2017
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry
Parts of work: Abramsson A, Kettunen P, Banote RK, Lott E, Li M, Arner A, Zetterberg H. The zebrafish amyloid precursor protein-b is required for motor neuron guidance and synapse formation. Dev Biol. 2013; 15;381(2):377-88.
VIEW ARTICLE


Banote RK, Edling M, Eliassen F, Kettunen P, Zetterberg H, Abramsson A. β-Amyloid precursor protein-b is essential for Mauthner cell development in the zebrafish in a Notch-dependent manner. Dev Biol. 2016; 1;413(1):26-38.
VIEW ARTICLE


Banote RK, Edling M, Şatır TM, Burgess SM, Chebli J, Abramsson A, Zetterberg H. Characterization of β-amyloid precursor protein-b zebrafish mutants during early development. Manuscript

Abramsson A, Banote RK, Gobom J, Hansson KT, Blennow K, Zetterberg H. Quantitative proteomics analysis of amyloid precursor protein hypomorphic zebrafish (Danio rerio) embryos using TMT 10-plex isobaric labeling. Manuscript
Date of Defence: 2017-06-16
Disputation: Fredagen den 16 juni 2017, kl. 9.00, Hjärtats Aula, Blå stråket 5, Sahlgrenska Universitetssjukhuset, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Amyloid precursor protein
Zebrafish
Spinal cord
Motor neurons
Hindbrain
Mauthner cell
Development
Proteomics
Abstract: Amyloid precursor protein (APP) is a type-one membrane-spanning protein with a large extracellular N-terminal domain and a small intracellular C-terminal domain. APP first gained interest due to its involvement in the pathogenesis of Alzheimer’s disease (AD). Its proteolytic processing liberates the neurotoxic amyloid-beta (Aβ) peptide that accumulates in the amyloid plaques, characteristic of AD. Thus, APP has been intensively studied for its amyloidogenic properties with less focus on its... more
ISBN: 978-91-629-0212-4 (PRINT)
978-91-629-0211-7 (PDF)
URI: http://hdl.handle.net/2077/51893
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

 

 

© Göteborgs universitet 2011