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Novel Tumor Suppressor Gene Candidates in Experimental Endometrial Carcinoma - From Cytogenetic to Molecular Analysis
(2009-08-28)
Endometrial carcinoma (EC) is the most common form of gynecological malignancy, ranking fourth in incidence among tumors diagnosed in women. As is the case with other complex diseases, detailed analyses of the underlying ...
Identification of novel BRCA2-binding proteins that are essential for meiotic homologous recombination
(2021-01-27)
Meiotic recombination is a molecular process in which the induction and repair of programmed DNA double-strand breaks (DSBs) creates genetic exchange between homologous chromosomes and thus increases genetic diversity and ...
The molecular chaperone CCT: Functions beyond folding
(2021-10-07)
The chaperonin-containing tailless complex polypeptide 1 (CCT) is a eukaryotic ~1 MDa barrel shaped molecular chaperone, built up by eight distinct subunits and is required for the folding of the abundant cytoskeletal ...
Analyses of Rat Tumor Models for DMBA-induced Fibrosarcoma and Spontaneous Endometrial Carcinoma
(2008-10-20)
Cancer is a disease of genes. Uncontrolled cell growth is the outcome from genetic as well as epigenetic alterations, resulting in a tumor cell mass that harbors a cancer genome. During progression, the tumor acquires ...
Modeling and exploring human IRE1 as a strategy to design novel inhibitors: a computational approach
(2019-12-12)
Inositol Requiring Enzyme 1 (IRE1) is a bifunctional
serine/threonine kinase and endoribonuclease that is the major mediator of
the Unfolded Protein Response (UPR) during endoplasmic reticulum (ER) stress.
The association ...