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Identification of novel BRCA2-binding proteins that are essential for meiotic homologous recombination


Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/67213

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Title: Identification of novel BRCA2-binding proteins that are essential for meiotic homologous recombination
Authors: Zhang, Jingjing
E-mail: jingjing.zhang@gu.se
Issue Date: 27-Jan-2021
University: University of Gothenburg. Faculty of Science
Institution: Department of Chemistry and Molecular Biology ; Institutionen för kemi och molekylärbiologi
Parts of work: Paper I. A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination. Jingjing Zhang*, Yasuhiro Fujiwara*, Shohei Yamamoto, Hiroki Shibuya† Nature Communications. 2019.10:722
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Paper II. The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells. Jingjing Zhang*, Manickam Gurusaran*, Yasuhiro Fujiwara*, Kexin Zhang, Meriem Echbarthi, Egor Vorontsov, Rui Guo, Devon F Pendlebury, Intekhab Alam, Gabriel Livera, Martini Emmanuelle, P Jeremy Wang, Jayakrishnan Nandakumar, Owen R Davies, Hiroki Shibuya† Nature Communications. 2020.11:2055
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Paper III. Structural basis of BRCA2 recruitment to meiotic recombination sites. Devon F. Pendlebury*, Jingjing Zhang*, Ritvija Agrawal, Hiroki Shibuya† and Jayakrishnan Nandakumar† Manuscript (2021)
Date of Defence: 2021-02-26
Disputation: fredagen den 26 Februari 2021 kl. 14.00 i Arvid Carlsson,Medicinaregatan 3
Degree: Doctor of Philosophy
Publication type: Doctoral thesis
Keywords: meiosis
DSB
cancer
BRCA2
MEILB2
BRME1
HR
RAD51
DMC1
DDR
Abstract: Meiotic recombination is a molecular process in which the induction and repair of programmed DNA double-strand breaks (DSBs) creates genetic exchange between homologous chromosomes and thus increases genetic diversity and ensures chromosome segregation. Breast cancer susceptibility gene 2 (BRCA2) is a potent cancer suppressor and is required for DSB repair by homologous recombination (HR) in mitosis. However, due to the embryonic lethality of the Brca2 knockout (KO) mice, the role of BRCA2 in me... more
ISBN: 978-91-8009-166-4
978-91-8009-167-1
URI: http://hdl.handle.net/2077/67213
Appears in Collections:Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kemi och molekylärbiologi

 

 

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