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Studies on glycosphingolipids in regenerative medicine

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Title: Studies on glycosphingolipids in regenerative medicine
Authors: Barone, Angela
Issue Date: 9-May-2014
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Surgery
Parts of work: I. Barone Structural complexity of non-acid glycosphingolipids in human embryonic stem cells grown under feeder-free conditions. J Biol Chem. 2013 Apr 5;288(14):10035-50.

II. Barone et. al. Sialyl-lactotetra: a novel cell surface marker of pluripotent undifferentiated human stem cells. 2014 Submitted manuscript.

III. Barone et. al. Characterization of acid and non-acid glycosphingolipids of porcine heart valves as potential immune targets in biological heart valve grafts. 2014 Submitted manuscript
Date of Defence: 2014-05-28
Disputation: Onsdagen den 28 maj 2014, kl. 13.00, Hörsal Ragnar Sandberg, Medicinaregatan 7A
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Glycosphingolipids
human embryonic stem cells
Cell surface markers
porcine heart valves
regenerative medicinr
Abstract: Regenerative medicine, including stem cell based therapies and xenotransplantation, is a new and developing field that aims to restore normal function in end stage cell/organ failure. However, in therapeutic settings involving transfer of cells with a different genetic background, these cells will expose the recipient to non-self cell surface antigenic determinants that may evoke an immune response and subsequent graft damage. Thus, the cell surface antigen expression of cells aimed for transpla... more
ISBN: 978-91-628-9040-7
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper



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