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Neuronal networks involved in low back pain; experimental studies


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Title: Neuronal networks involved in low back pain; experimental studies
Authors: Nilsson, Elin
E-mail: elin.nilsson@physiol.gu.se
Issue Date: 8-Oct-2012
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Physiology
Parts of work: I. Galea, MP, Hammar, I, Nilsson, E, Jankowska, E. Bilateral postsynaptic actions of pyramidal tract and reticulospinal neurons on feline erector spinae motoneurons. Journal of Neuroscience 2010; 30(3), 858-69.
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II. Nilsson, E, Brisby, H, Rask, K, Hammar, I. Mechanical compression and nucleus pulposus application on dorsal root ganglia differentially modify evoked neuronal activity in the thalamus. Submitted.

III. Nilsson, E, Larsson, K, Rydevik, B, Brisby, H, Hammar, I. Evoked thalamic neuronal activity following DRG application of two nucleus pulposus derived cell populations: an experimental study in rats. Submitted.
Date of Defence: 2012-10-25
Disputation: Torsdagen den 25 oktober, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: low back pain
disc herniation
pyramidal tract
reticulospinal tract
longissimus muscle
nucleus pulposus
VPL
thalamus
rat
cat
Abstract: Low back pain is a common cause of disability, with a lifetime prevalence of up to 80%. A lumbar disc herniation, involving a bulging disc and/or leakage of the intervertebral disc’s nucleus pulposus, may be a possible cause of back and sciatic pain. Low back pain has also been associated with dysfunctional control of the paraspinal muscles. The aim of this thesis was to study the neuronal networks involved in low back pain including sciatica. In paper I, the contribution of two descending tract... more
ISBN: 978-91-628-8496-3
URI: http://hdl.handle.net/2077/29721
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi

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