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Body fat regulating neuropeptides: relation to interleukines and gut microbiota


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Title: Body fat regulating neuropeptides: relation to interleukines and gut microbiota
Authors: Schéle, Erik
E-mail: erik.schele@gu.se
Issue Date: 25-May-2012
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Physiology
Parts of work: Paper 1. Erik Schéle, Anna Benrick, Louise Grahnemo, Emil Egecioglu, John-Olov Jansson. (2012). Interrelation between interleukin-1 (IL-1), IL-6 and body fat regulating circuits of the hypothalamic arcuate nucleus. Unpublished manuscript.

Paper 2. Anna Benrick, Erik Schéle, Scarlett Pinnock, Ingrid Wernstedt-Asterholm, Suzanne Dickson, Linda Karlsson-Lindahl, John-Olov Jansson. Interleukin-6 gene knockout influences energy balance regulating peptides in the hypothalamic paraventricular and supraoptic nuclei. Journal of Neuroendocrinology. 2009 Jul;21(7):620-8. Epub 2009 Apr 13.
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Paper 3. Erik Schéle, Csaba Fekete, Péter Egri, Tamás Füzesi, Miklós Palkovits, Éva Keller, Zsolt Liposits, Balázs Gereben, Linda Karlsson-Lindahl, Ruijin Shao, John-Olov Jansson. Interleukin-6 receptor a is co-localised with melanin-concentrating hormone in human and mouse hypothalamus. Journal of Neuroendocrinology. Epub 2012 Feb 1.
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Paper 4. Erik Schéle, Louise Grahnemo, Fredrik Anesten, Anna Hallén, Fredrik Bäckhed, John-Olov Jansson. (2012). The gut microbiota inhibits the expression of the obesity suppressing neuropeptides brain-derived neurotrophic factor (BDNF) and proglucagon in the hypothalamus and the brainstem. Unpublished manuscript.
Date of Defence: 2012-06-05
Disputation: Tisdagen den 5 juni 2012, kl. 13.00, Hörsal Ivan Östholm, Medicinaregatan 13 A
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: IL-6
IL-6 receptor a
obesity
hypothalamus
brainstem
immunohistochemistry
Abstract: Previous studies have shown that mice lacking interleukin-6 (IL-6), an important cytokine in the immune system, develop obesity, and that central, but not peripheral, administration of IL-6 induces energy expenditure. These findings suggest that IL-6 suppresses fat mass through the central nervous system. The mechanism behind this, however, is not understood. The aim of this thesis was to investigate possible neurobiological mechanisms, by which IL-6, during health, could exert its fat suppres... more
ISBN: 9789162884383
URI: http://hdl.handle.net/2077/28954
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses from Sahlgrenska Academy

 

 

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