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Astrocyte-mediated short-term synaptic depression


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Title: Astrocyte-mediated short-term synaptic depression
Authors: Andersson, My
E-mail: my.andersson@physiol.gu.se
Issue Date: 9-Sep-2009
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Physiology
Parts of work: I. My Andersson and Eric Hanse. Astrocytes impose post burst depression of release probability at hippocampal glutamate synapses. Manuscript.

II. My Andersson, Fredrik Blomstrand and Eric Hanse. Astrocytes play a cirtical role in transient heterosynaptic depression in the rat hippocampal CA1 region. J Physiol. 2007 Dec 15;585(Pt 3):843-52
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III. My Andersson and Eric Hanse. Astrocyte-mediated short-term synaptic depression in the rat hippocampal CA1 area: two modes of decreasing release probability. Manuscript.
Date of Defence: 2009-09-17
Disputation: Fredagen den 17 september kl 13:00, Hörsal Ivan Östholm, Medicinaregatan 13, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: glutamate
glia
plasticity
synapse
hippocampus
Abstract: Short-term synaptic plasticity, the activity-dependent regulation of synaptic efficacy that occurs in the timeframe of milliseconds to seconds, is a fundamental property of the synapse, mostly attributed to changes in release probability. These changes are commonly ascribed to intrinsic mechanisms in the presynaptic terminal and to different transmitters acting on the presynaptic terminal. Astrocytes are the most abundant cell type in the brain. It has become increasingly clear that they can hav... more
ISBN: 978-91-628-7871-9
URI: http://hdl.handle.net/2077/20443
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet

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