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Applied Population Pharmacokinetic/ Pharmacodynamic Modeling of Antiretroviral and Antimalarial Drug Therapy

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Title: Applied Population Pharmacokinetic/ Pharmacodynamic Modeling of Antiretroviral and Antimalarial Drug Therapy
Authors: Röshammar, Daniel
Issue Date: 2-Feb-2009
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Neuroscience and Physiology. Department of Pharmacology
Parts of work: I. Mukonzo J, Röshammar D, Waako P, Andersson M, Fukasawa T, Milani L, Svensson J-O, Ogwal-Okeng J, Gustafsson LL, Aklillu E (2008) A novel polymorphism in MDR1 gene, CYP2B6*6 and sex predict single dose efavirenz population pharmacokinetics in Ugandans. Submitted

II. Nyakutira C, Röshammar D, Chigutsa E, Chnozi P, Ashton M, Nhachi C, Masimirembwa C (2008) High prevalence of the CYP2B6 516GT(*6) variant and effect on the population pharmacokinetics of efavirenz in HIV/AIDS outpatients in Zimbabwe. Eur J Clin Pharm 64: 357-365

III. Röshammar D, Josephson F, Simonsson USH, Ekvall H, Flamholc L, Ormaasen V, Sönnerborg A, Wallmark E, Ashton M, Gisslén M (2009) Assessment of antiretroviral drug efficacy in the NORTHIV study by non-linear mixed effects modeling. Manuscript

IV. Röshammar D, Hai TN, Thanh NV, Huong DX, Huong NV, Thu NB, Ashton M (2007) Modeling of the time-dependent population pharmacokinetics and exposure-response relationship of the antimalarial artemisinin based on sparsely sampled saliva. Manuscript

V. Röshammar D, Hai TN, Friberg Hietala S, Huong NV, Ashton M (2006) Pharmacokinetics of pipearquine after repeated oral administration of CV8 in 12 healthy male subjects. Eur J Clin Pharm 62: 335-41

Date of Defence: 2009-02-20
Disputation: Fredagen den 20 februari 2009, kl. 13.00, Föreläsningssalen, LNC, Medicinaregatan 13A, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: HIV, malaria, pharmacokinetics, pharmacodynamics, pharmacometrics, NONMEM
Abstract: HIV/AIDS and malaria are two major global infectious diseases. Although better drugs against these conditions are becoming more available, dosages may not always be optimal with respect to effectiveness, safety, cost or convenience of administration. This thesis aims to quantitate the pharmacological relationship between dosing history, sources of variation between individuals, drug exposure and response to selected antiretroviral and antimalarial regimens. Pharmacometric, i.e. pharmaco-statist... more
ISBN: 978-91-628-7667-8
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för neurovetenskap och fysiologi
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses from Sahlgrenska Academy



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