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Novel approaches to mucosal vaccine development Strategies in vaccine antigen production, construction of a novel mucosal adjuvant and studies of its mode of action
(2019-11-13)
Although most infections begin at a mucosal surface and may be prevented by effective vaccine stimulation of the local mucosal immune system, there are so far only a few mucosal vaccines available for human use. This thesis ...
On Neuroimmunology and Brain Function: Experimental and Clinical Studies
(2019-05-23)
The immune system has been implicated in the mechanisms underlying many psychiatric disorders. Immune mediators are expressed in the central nervous system (CNS) not only in response to harmful stimuli, but also in a ...
Direct triaging to physiotherapist in primary care - development and evaluation of a triage model
(2019-04-05)
Background: There is evidence that early contact with physiotherapists leads to advantages for patients with musculoskeletal disorders. Many patients, however, initially seek contact with general practitioners (GPs) within ...
Mean systemic filling pressure - from Guyton to the ICU, and back again
(2019-02-01)
Introduction: Mean systemic filling pressure (MSFP) is the equilibrated vascular pressure at zero flow. Venous return (VR) driving pressure (VRdP) is the difference between MSFP and right atrial pressure (RAP). In clinical ...
Chronic Rhinosinusitis with Nasal Polyps - Symptoms, Heredity and Genetics
(2019-04-26)
ABSTRACT
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by long-term inflammation of the paranasal sinuses combined with bilateral glassy protuberances from the middle meatus of the nasal cavity. This ...
Pain in Osteoarthritic Joints: Biological Signaling and 3D Models based on Imaging
(2019-12-19)
Osteoarthritis (OA) is the most common joint disease, causing disability in middle-aged and elderly patients worldwide and imposing a huge socioeconomic burden. OA of the knee joint is a major cause of joint pain and, along ...
International Outcomes of Total Hip Arthroplasty: Influence of Patient, Implant, and Surgical factors on Total Hip Arthroplasty Survivorship in Sweden, the US, and Australia
(2019-05-22)
Abstract
Background
Hip osteoarthritis (OA) is debilitating disease resulting in pain, stiffness, and reduced physical function. Although total hip arthroplasty (THA) is a successful treatment for OA, some THAs require ...
Sköldkörtelsjukdom i Ronneby
(Arbets- och miljömedicin, Göteborgs universitet, 2019-06-28)
I december 2013 upptäcktes höga halter av högfluorerade ämnen (så kallade PFAS) i ett vattenverk, som försörjde ⅓ av hushållen i Ronneby kommun med dricksvatten. För att undersöka om PFAS-föroreningen har lett till en ökad ...
Genome-wide epigenetic profiling of B cell leukemia and lymphoma
(2019-12-06)
Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, ...
Tonsil Surgery - Register Studies of Complications and Outcomes
(2019-11-07)
Tonsillectomy is a commonly performed surgical procedure yet the evidence of the effect in patients with recurrent/chronic throat infections is unsatisfactory. Great variations exist in the reported rates of postoperative ...