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Now showing items 11-20 of 159
Taurine and dopamine-related effects of ethanol. An experimental study in rodents
(2019-11-18)
The reinforcing properties of alcohol (ethanol) are associated with activation of the mesolimbic dopamine system and the concomitant increase in dopamine in the nucleus accumbens (nAc). Changes in this system are thought ...
Understanding the role of long non-coding RNAs in neuroblastoma development and progression
(2019-11-11)
Neuroblastoma (NB), a common cancer of childhood, contributes to 15% of all pediatric cancer deaths. The improper neuronal differentiation of neural crest cells to mature neurons in the sympathetic nervous system leads to ...
Towards restoring intestinal health after pelvic radiotherapy - Lessons from dietary fiber intervention in a novel mouse model
(2019-11-18)
Patients who have cancer in the pelvic region are at risk of developing gastrointestinal symptoms for weeks, months, or even years after receiving radiotherapy. These symptoms are triggered due to unwanted radiation-induced ...
On detection, treatment and prevention of complications in paediatric cataract surgery
(2019-11-06)
Purpose: To find and validate methods for diagnosis, treatment and prevention of complications in paediatric cataract surgery.
Background: Cataract and glaucoma are major treatable blinding conditions in children. Surgery ...
Computational exploration of cancer genomes
(2019-01-09)
Cancer evolves due to changes in DNA that give a cell an advantage at the expense of the remaining organism. These alterations range from individual base substitutions to broad losses or duplications of chromosomal material. ...
Citrobacter rodentium and Escherichia coli interactions with mucus producing colonic epithelical cells
(2019-11-06)
The epithelial cells together with the mucus layer protect the host from noxious luminal substances and pathogenic invasion. Pathogens have evolved numerous strategies to circumvent these barriers and mount infection. C. ...
Midwives’ Collective Attitude towards Labour Pain: Mixed Methods Research
(2019-02-08)
Background: The majority of women in Jordan give birth in public hospitals where midwives are the main birth attendants. Although most women have trust in their midwives, studies have reported women’s dissatisfaction with ...
The use of fibrinogen in cardiac surgery patients-clinical and experimental studies
(2019-10-30)
BACKGROUND Cardiac surgery with cardiopulmonary bypass impairs hemostasis due to hemodilution and consumption of platelets and coagulation factors, such as fibrinogen. The aim of this thesis was to study the role of ...
In vivo responses of neural progenitor cells to extracellular matrix signaling under pathological conditions
(2019-05-23)
The adult brain has an inherently low capacity for tissue regeneration, and neurons lost to disease or injuries are normally not replaced. This becomes especially apparent when stroke or brain trauma occurs. The discovery ...
On the Effects of Serotonin Reuptake Inhibitors in Major Depression
(2019-01-25)
This thesis focuses on the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) and how these are reflected by the Hamilton Depression Rating Scale (HDRS). To this end, we have assembled a large data ...