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Influence of inflammation and of stage of lung development on the development of neonatal lung injury
(2010-11-26)
Bronchopulmonary dysplasia (BPD) is a major cause of mortality and long-term morbidity in prematurely born infants. Pulmonary inflammation, and abnormal alveolar and vascular development of the lung are histological ...
Adiponectin, the metabolic syndrome and atherosclerosis. Observation and intervention studies
(2006)
Adiponectin (Adn) has beneficial effects on insulin- and glucose metabolism as well as anti-inflammatory properties. High Adn concentrations are associated with reduced risks for insulin resistance and future diabetes, and ...
Surgery and Ischemia in Uterus Transplantation. Studies in various experimental models.
(2007-09-10)
The use of transplantation to enhance quality of life is a growing clinical field that also includes transplantation of reproductive organs. Transplantation of the uterus has been suggested as future method to treat uterus ...
Regulation of IL-6-signaling and inflammatory response – Role of insulin, FOXO1 and PKCδ
(2010-04-27)
The aim of this thesis was to investigate if and how insulin antagonizes interleukin-6 (IL-6)-signaling and
action using both 3T3-L1 mouse adipocytes (Paper I) and HepG2 human hepatocytes (Paper III). We also
investigated ...
Cyclooxygenase activity and tumor progression
(2008-09-26)
Invasive growth of malignant tumors is associated with local and systemic inflammation, which may promote progression and metastases. Inflammation is also responsible for appearing manifestations of advanced cancer as ...
Cardiovascular structure and function in obesity. The impact of body composition, sleep apnea and sustained weight loss
(2012-10-23)
Background: Obesity is associated with disturbances in cardiovascular structure and function varying along with the degree of fatness, but the mechanisms underlying this co-variation are unclear. Short-term weight loss ...
Studies on the atherogenicity of apoB-containing lipoproteins in type 2 diabetes
(2009-01-15)
Type 2 diabetes (T2D) and the metabolic syndrome (MetS), two conditions that are rapidly increasing in prevalence, as well as the dyslipoproteinemia and subclinical inflammation characteristic for these conditions, are ...
Arthritogenecity of RNA and its degradation products
(2006)
Viral infections often lead to arthralgias and overt arthritic states. Expression of double stranded RNA (dsRNA) is a common feature of all viruses during their replication and it has been suggested that it is able to ...
Modeling and exploring human IRE1 as a strategy to design novel inhibitors: a computational approach
(2019-12-12)
Inositol Requiring Enzyme 1 (IRE1) is a bifunctional
serine/threonine kinase and endoribonuclease that is the major mediator of
the Unfolded Protein Response (UPR) during endoplasmic reticulum (ER) stress.
The association ...
Exhaled markers of oxidative stress in the airways
(2004)
Breath contains a number of different molecules, some of which may have potential use as markers for oxidative stress in the airways during chronic airway inflammation. The major objectives were to develop and validate ...