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Genetics of Parkinson's disease - with focus on genes of relevance for inflammation and dopamine neruon development
(2010-02-18)
Abstract
GENETICS OF PARKINSON’S DISEASE
- WITH FOCUS ON GENES OF RELEVANCE FOR INFLAMMATION AND DOPAMINE NEURON DEVELOPMENT
Introduction: The risk to be affected by Parkinson’s disease (PD) is considered to be ...
The role of neonatal immunity in preterm brain injury
(2016-11-23)
Perinatal brain injury is an important cause of mortality and morbidity and is associated with neurological disabilities such as those seen in cerebral palsy. Prematurity, especially in combination with very low birth ...
Interactions between whole blood and TiO₂ surfaces with focus on adhesion and activation of PMN granulocytes
(2000)
Foreign materials come in contact with the human body more and more frequently. The surgical procedure of inserting an implant into the body will cause bleeding, evoke an inflammatory response and initiate a healing process, ...
Antimicrobial peptides in the treatment of infectious and inflammatory conditions - Preclinical studies of mechanism of action, efficacy, and safety
(2016-10-20)
The rapid emergence of antibiotic-resistant microbes worldwide and the urgent need of new antimicrobial agents have stimulated interest in antimicrobial peptides (AMPs) as new therapeutics for treatment of infectious ...
The Role of the Autonomic Nervous System in Atherosclerosis - Targeting the Cholinergic Anti-inflammatory Pathway in Humans and Mice
(2017-01-20)
The autonomic nervous system (ANS) has been implicated in numerous atherosclerosis-induced cardiovascular disease, such as myocardial infarction and stroke. Although evidence suggests a relationship between autonomic ...
The role of bacterial endotoxin in the immature brain
(2004)
Aim: Epidemiological evidence suggests that infections may increase the vulnerability of the immature brain to further insults. The aim of this thesis was to investigate the role of bacterial endotoxin (lipopolysaccharide, ...
Pediatric Autoinflammatory Diseases: Conceptual, Clinical, and Mechanistic Dimensions
(2015-09-10)
This thesis focuses on three paediatric autoinflammatory diseases in Sweden today; familial Mediterranean fever (FMF), periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) and synovitis, acne, ...
Progression and treatment of experimental peri-implantitis
(2011-04-21)
Peri-implantitis is characterized by inflammatory lesions in peri-implant tissues and loss of supporting bone. The aims of the present series of studies were to analyze (i) spontaneous progression and (ii) the effect of ...
Inflammation and neuroprotective strategies in the immature brain after hypoxic-ischemic brain injury
(2008-05-13)
Perinatal brain injury, as a result of hypoxia-ischemia (HI) or infection/HI, is a major cause of acute mortality and neurological morbidity in infants and children. The mechanisms of perinatal HI are not fully understood, ...
Molecular and structural patterns of guided bone regeneration (GBR). Experimental studies on the role of GBR membrane and bone substitute materials
(2015-09-15)
The mechanisms of guided bone regeneration (GBR) and bone healing with calcium phosphate (CaP) bone substitutes are not fully understood. The major aim of this thesis was to determine the relationship between the bone ...