Search
Now showing items 1-10 of 25
Regulation of the platelet-derived growth factor β-receptor
(2001)
Growth factors are important signalling molecules, regulating cell growth, as well as cell movement, differentiation and apoptosis. They bind to specific receptors on the cell surface causing activation of the receptors. ...
Properties of the endothelial cells and the glomerular barrier
(2000)
The kidneys are vital organs that filter plasma to produce 180 liters of primary urine per day. Only 1% of this volume is excreted and the rest is reabsorbed. Naturally, such huge amounts of fluid must be well controlled ...
The inflammatory and immunogenic properties of the receptor for advanced glycation end products and its ligand, high mobility group box chromosomal protein 1
(2005)
Rheumatoid arthritis (RA) is a chronic systemic inflammatory joint disease, the pathogenesis of which is complex, involving a wide range of molecules. High mobility group box chromosomal protein 1 (HMGB1) is a nuclear ...
The renin-angiotensin system in renal tubulogenesis. Experimental studies in the rat
(2004)
The kidney and the renin-angiotensin system (RAS) are vital regulators of blood pressure and salt-water balance. In order to appropriately regulate circulatory homeostasis, the kidney must undergo normal development, in ...
On the initial inflammatory response to variations in biomaterial surface chemistry
(2004)
Aims. The aim of the present thesis was, firstly, to develop in vivo and ex vivo models for analysis of peri-implant exudate and implant adherent cells and, secondly, to characterize the early inflammatory response to ...
Interactions between whole blood and TiO₂ surfaces with focus on adhesion and activation of PMN granulocytes
(2000)
Foreign materials come in contact with the human body more and more frequently. The surgical procedure of inserting an implant into the body will cause bleeding, evoke an inflammatory response and initiate a healing process, ...
The role of bacterial endotoxin in the immature brain
(2004)
Aim: Epidemiological evidence suggests that infections may increase the vulnerability of the immature brain to further insults. The aim of this thesis was to investigate the role of bacterial endotoxin (lipopolysaccharide, ...
Inflammation and neuroprotective strategies in the immature brain after hypoxic-ischemic brain injury
(2008-05-13)
Perinatal brain injury, as a result of hypoxia-ischemia (HI) or infection/HI, is a major cause of acute mortality and neurological morbidity in infants and children. The mechanisms of perinatal HI are not fully understood, ...
Secretory and anti-inflammatory actions of some gastro-intestinal hormones in salivary glands
(2009-09-17)
Textbooks generally state that the secretory activity of salivary glands is solely regulated by nerves. This view is challenged in the present Thesis, using the parotid gland of the anaesthetized rat as experimental in ...
Regional differences in the response of neural stem cells and their microenvironment to ionizing radiation
(2009-05-14)
Radiation therapy is one of the most effective tools for treating malignant tumors; however, cranial irradiation often results in intellectual impairment and cognitive deficits, such as impaired learning and memory. Ionizing ...