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Mechanisms of Lung Injury in a Mouse Model of Bronchopulmonary Dysplasia
(2009-11-26)
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects preterm infants. Increased levels of inflammatory mediators in the amniotic fluid and in the lungs of preterm infants are associated with the development ...
Studies on mechanisms of biocompatibility elicited at blood-material interfaces : effects of surface adsorbed plasma proteins, protein-cell and cell-cell interactions at biomaterial surfaces
(1997)
Biomaterials are used in the construction of medical devices intended to be in intimate contact with blood and tissues of the human body. For many of the biomaterials in direct contact with blood, the dominant mechanism ...
Resistin is a modulator of inflammation and autoimmunity
(2009-11-18)
Resistin is a protein with proinflammatory properties in man and a regulator of glucose
metabolism in mice. Human resistin activates the nuclear factor kappa-B dependent
cytokine cascade; however, its full role in ...
Influence of inflammation and of stage of lung development on the development of neonatal lung injury
(2010-11-26)
Bronchopulmonary dysplasia (BPD) is a major cause of mortality and long-term morbidity in prematurely born infants. Pulmonary inflammation, and abnormal alveolar and vascular development of the lung are histological ...
Adiponectin, the metabolic syndrome and atherosclerosis. Observation and intervention studies
(2006)
Adiponectin (Adn) has beneficial effects on insulin- and glucose metabolism as well as anti-inflammatory properties. High Adn concentrations are associated with reduced risks for insulin resistance and future diabetes, and ...
Surgery and Ischemia in Uterus Transplantation. Studies in various experimental models.
(2007-09-10)
The use of transplantation to enhance quality of life is a growing clinical field that also includes transplantation of reproductive organs. Transplantation of the uterus has been suggested as future method to treat uterus ...
Regulation of IL-6-signaling and inflammatory response – Role of insulin, FOXO1 and PKCδ
(2010-04-27)
The aim of this thesis was to investigate if and how insulin antagonizes interleukin-6 (IL-6)-signaling and
action using both 3T3-L1 mouse adipocytes (Paper I) and HepG2 human hepatocytes (Paper III). We also
investigated ...
Cyclooxygenase activity and tumor progression
(2008-09-26)
Invasive growth of malignant tumors is associated with local and systemic inflammation, which may promote progression and metastases. Inflammation is also responsible for appearing manifestations of advanced cancer as ...
Cardiovascular structure and function in obesity. The impact of body composition, sleep apnea and sustained weight loss
(2012-10-23)
Background: Obesity is associated with disturbances in cardiovascular structure and function varying along with the degree of fatness, but the mechanisms underlying this co-variation are unclear. Short-term weight loss ...
Studies on the atherogenicity of apoB-containing lipoproteins in type 2 diabetes
(2009-01-15)
Type 2 diabetes (T2D) and the metabolic syndrome (MetS), two conditions that are rapidly increasing in prevalence, as well as the dyslipoproteinemia and subclinical inflammation characteristic for these conditions, are ...