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Multi-level characterization of host and pathogen in Helicobacter pylori-associated gastric carcinogenesis
(2014-11-06)
Today, more than half of the world’s population is infected with Helicobacter pylori, and two to three per cent of these will develop gastric cancer associated with this infection. Gastric cancer is today the third largest ...
Intravoxel incoherent motion modeling - Optimization of acquisition, analysis and tumor tissue characterization
(2018-09-13)
Intravoxel incoherent motion (IVIM) analysis provides a means to obtain information on diffusion and perfusion from a single MRI sequence. The measurements are completely noninvasive and the results have been shown to be ...
Mediator and cell cycle regulation
(2015-11-04)
The multiprotein Mediator complex is an evolutionarily conserved coregulator of eukaryotic transcription. Mediator functions as a bridge between gene-specific transcription factors and the RNA polymerase II transcription ...
From 1p3 to PI3K - Studies of neuroblastoma
(2011-01-19)
Neuroblastoma (NB) is a tumor of the sympathetic nervous system and is the most common extra-cranial tumor of childhood, accounting for 7% of all pediatric malignancies. Despite recent advances in therapeutics, outcome is ...
Obesity - surgical treatment and molecular mechanisms
(2015-11-11)
Obesity is a condition of high prevalence and is associated with increased morbidity and mortality. Bariatric surgery is an effective treatment of obesity and reduces the risk for morbidity and mortality, but little is ...
The susceptibility to metabolic and proliferative diseases - from genetic predisposition to treatment
(2014-05-05)
Obesity and type 2 diabetes increase the risk of cardiovascular disease. Insulin resistance is highly correlated to type 2 diabetes and both obesity and insulin resistance are risk factors for cancer. Bariatric surgery is ...
TGF-beta signaling in cancer
(2010-11-19)
Transforming Growth Factor beta (TGF-beta) is a cytokine regulating a wide range of cellular processes such as proliferation, differentiation, and migration. At the early stages of cancer development TGF-beta functions as ...
Targeting NOX2 in cancer
(2018-02-27)
Reactive oxygen species (ROS) are short-lived, toxic derivatives of oxygen that are produced during mitochondrial respiration and by NADPH oxidases (NOX). By enzymatically generating ROS, the myeloid cell NOX2 plays a ...
Modeling and exploring human IRE1 as a strategy to design novel inhibitors: a computational approach
(2019-12-12)
Inositol Requiring Enzyme 1 (IRE1) is a bifunctional
serine/threonine kinase and endoribonuclease that is the major mediator of
the Unfolded Protein Response (UPR) during endoplasmic reticulum (ER) stress.
The association ...
Hutchison-Gilford Progeria Syndrome – A new treatment strategy and the role of prelamin A in oncogenesis
(2014-04-25)
Prelamin A, a CaaX-protein is a key structural protein of the inner nuclear lamina, a meshwork lining the inner
nuclear envelope. Farnesylated prelamin A is cleaved just upstream of the farnesylcysteine residue to ...