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Targeting NOX2 in cancer


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Title: Targeting NOX2 in cancer
Authors: Aydin, Ebru
E-mail: ebru.aydin@gu.se
Issue Date: 27-Feb-2018
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Infectious Diseases
Parts of work: I. Martner, Anna, et al. "Histamine promotes the development of monocyte-derived dendritic cells and reduces tumor growth by targeting the myeloid NADPH oxidase." The Journal of Immunology 194.10 (2015): 5014-5021.
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II. Aydin, Ebru, et al. "Role of NOX2-Derived Reactive Oxygen Species in NK Cell–Mediated Control of Murine Melanoma Metastasis." Cancer immunology research 5.9 (2017): 804-811.
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III. Grauers Wiktorin, Hanna, et al. "Role of NOX2 for leukaemic expansion in a murine model of BCR‐ABL1+ leukaemia." British journal of haematology (2017).
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IV. Aydin, Ebru, et al. "NOX2 inhibition reduces oxidative stress and prolongs survival in murine KRAS-induced myeloproliferative disease." Submitted
Date of Defence: 2018-03-20
Disputation: Tisdagen den 20 mars 2018, kl. 9.00, Hörsal Carl Kylberg, Medicinaregatan 7, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: cancer
reactive oxygen species
immunotherapy
nox2
nk cells
melanoma
histamine
metastasis
leukemia
aml
cml
kras
mpd
Abstract: Reactive oxygen species (ROS) are short-lived, toxic derivatives of oxygen that are produced during mitochondrial respiration and by NADPH oxidases (NOX). By enzymatically generating ROS, the myeloid cell NOX2 plays a critical role in defense against bacteria and other microorganisms. The NOX2-derived ROS have also been ascribed immunosuppressive properties and may damage DNA to induce mutagenesis, but details regarding the role of NOX2 and ROS for the initiation and progression of cancer are pa... more
ISBN: 978-91-629-0444-9 (pdf)
978-91-629-0445-6 (print)
URI: http://hdl.handle.net/2077/54537
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

 

 

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