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Hutchison-Gilford Progeria Syndrome – A new treatment strategy and the role of prelamin A in oncogenesis


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Title: Hutchison-Gilford Progeria Syndrome – A new treatment strategy and the role of prelamin A in oncogenesis
Authors: Ibrahim, Mohamed
E-mail: mohamed.ibrahim@gu.se
Issue Date: 25-Apr-2014
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Molecular and Clinical Medicine
Parts of work: I. Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria. Ibrahim MX, Sayin VI, Akula MK, Liu M, Fong LG, Young SG, Bergo MO. Science. 2013 Jun 14;340(6138):1330-3. doi: 10.1126/science.1238880. Epub 2013 May 16.
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II. Prelamin A inhibits K-RAS and B-Raf induced invasion but is dispensable for tumorgenesis. Manuscript. Ibrahim MX, Sayin VI, Bergo MO.
Date of Defence: 2014-05-15
Disputation: Torsdagen den 15 maj 2014, kl.9.00, Hörsal Ivan Östholm, Medicinaregatan 13(LNC)
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: progeria
cancer
Abstract: Prelamin A, a CaaX-protein is a key structural protein of the inner nuclear lamina, a meshwork lining the inner nuclear envelope. Farnesylated prelamin A is cleaved just upstream of the farnesylcysteine residue to produce mature lamin A. We generated Zmpste24 knockout mice and documented a striking accumulation of farnesylated and methylated prelamin A in cells. Zmpste24 knockout cells exhibit premature senescence and misshapen cell nuclei. Zmpste24 knockout mice show slow growth, hair loss,... more
ISBN: 978-91-628-9043-8
978-91-628-9014-8
URI: http://hdl.handle.net/2077/35196
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin

 

 

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