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Multi-level characterization of host and pathogen in Helicobacter pylori-associated gastric carcinogenesis

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Title: Multi-level characterization of host and pathogen in Helicobacter pylori-associated gastric carcinogenesis
Authors: Thorell, Kaisa
Issue Date: 6-Nov-2014
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Microbiology and Immunology
Parts of work: I. Nookaew I, Thorell K, Worah K, Wang S, Hibberd ML, Sjövall H, Pettersson S, Nielsen J, and Lundin SB. Transcriptome signatures in Helicobacter pylori-infected mucosa identifies acidic mammalian chitinase loss as a corpus atrophy marker. BMC Med Genomics. 2013 Oct 11;6:41 .

II. Thorell K, Hosseini S, Palacios Gonzáles RV, Chaotham C, Graham DY, Paszat L, Rabeneck L, Lundin SB, Nookaew I, and Sjöling Å. Identification of a Latin American specific babA variant through whole genome sequencing of Helicobacter pylori patient isolates from Nicaragua. Submitted for publication.

III. Thorell K, Karlsson R, Hosseini S, Kenny D, Sihlbom C, Karlsson A, Sjöling Å, and Nookaew I. Comparative proteomes of two Helicobacter pylori strains using genomics and mass spectrometry-based proteomics. Manuscript.

IV. Thorell K, Bengtson-Palme J, Liu O, Nookaew I, Paszat L, Nielsen J, Lundin SB, and Sjöling Å. In vivo analysis of the viable microbiota and Helicobacter pylori transcriptome in gastric infection and early stages of carcinogenesis. Manuscript.

V. Thorell K, Andersson Y, Gatto F, Fassan M, El-Zimaity H, Paszat L, Nookaew I, Sjöling Å, Nielsen J, and Lundin SB. Transcriptome analysis reveals differential expression of kynurenine pathway enzymes in Helicobacter pylori-induced gastric inflammation. Manuscript
Date of Defence: 2014-11-28
Disputation: Fredagen den 28 november, kl 9.00, sal Ivan Östholm, Medicinaregatan 13
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: gastroenterology
Helicobacter pylori
Abstract: Today, more than half of the world’s population is infected with Helicobacter pylori, and two to three per cent of these will develop gastric cancer associated with this infection. Gastric cancer is today the third largest cause of cancer mortality worldwide, with more than 700 000 deaths annually, a number that is expected to increase. H. pylori is usually acquired in childhood, and establish a lifelong infection in the absence of treatment. However, most infected individuals remain asymptomati... more
ISBN: 978-91-628-9168-8
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin



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