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dc.contributor.authorAhlner, Felicia
dc.date.accessioned2023-04-25T09:17:49Z
dc.date.available2023-04-25T09:17:49Z
dc.date.issued2023-04-25
dc.identifier.isbn978-91-8069-231-1 (tryckt)
dc.identifier.isbn978-91-8069-232-8 (PDF)
dc.identifier.urihttps://hdl.handle.net/2077/75188
dc.description.abstractBackground: Alcohol consumption is a major contributor to global morbidity and mortality, as well as accidents and intentional injuries. Older adults may be particularly susceptible to these negative consequences due to age-related factors that increase vulnerability to the adverse effects of alcohol. The overall aim of this thesis was to investigate alcohol consumption patterns in population-based samples of older adults by examining the prevalence, time trends, associated factors across specific levels of consumption, and the influence of alcohol on all-cause mortality. Method: Data were obtained from the Gothenburg H70 Birth Cohort studies, and study samples (≥70 years of age) included Birth cohorts 1906-07, 1922, 1930, and 1944, with a particular focus on Birth cohort 1944. Results: Paper I outlined the methodology employed during the baseline examination of Birth cohort 1944 conducted between 2014 and 2016, serving as the foundation for all papers in this thesis. Paper II examined changes in alcohol consumption among four birth cohorts of 70-year-olds examined across four decades, showing a significant upward trend in consumption rates, especially among women. Risk consumption increased from 7.4% (16.1% in men, 0.5% in women) in 1976-77 to 34.0% (45.3% in men, 24.3% in women) in 2014-16. In Paper III, substantial discrepancies in sociodemographic, social and health-related factors across different levels of consumption were revealed, with former drinking associated with the most unfavorable set of factors. Further, characteristics varied significantly among 70-year-olds who exceeded low-risk drinking guidelines for older adults. Paper IV investigated the impact of alcohol on all-cause mortality in individuals with a baseline age of 70 years over an 8-year follow-up period. The study also evaluated the combined effect of lifestyle factors on mortality risk using a 7-item risk score. The findings suggested that alcohol consumption has no independent effect on all-cause mortality, but its impact was moderated by physical activity. Moreover, individuals fulfilling criteria for at least five lifestyle risk factors had up to four times higher risk of all-cause mortality. Conclusion: Recent generations of 70-year-olds exhibited higher alcohol consumption rates, yet with few negative consequences, both cross-sectionally and longitudinally. However, consuming alcohol at rates approximately 2.5 times higher than current age-specific guidelines was associated with traditional alcohol-attributable consequences. In addition, a combination of alcohol overconsumption and several unhealthy lifestyle risk factors increased the risk of mortality. The knowledge gained from this thesis could be used to inform public health policies and interventions aimed at reducing harmful alcohol consumption in this particular age group.en
dc.language.isoengen
dc.relation.haspartI. Rydberg Sterner T*, Ahlner F*, Blennow K, Dahlin-Ivanoff S, Falk H, Havstam Johansson L, Hoff M, Holm M, Hörder H, Jacobsson T, Johansson B, Johansson L, Kern J, Kern S, Machado A, Mellqvist Fässberg M, Nilsson J, Ribbe M, Rothenberg E, Rydén L, Sadeghi A, Sacuiu S, Samuelsson J, Sigström R, Skoog J, Thorvaldsson V, Waern M, Westman E, Wetterberg H, Zetterberg H, Zetterberg M, Zettergren A, Östling S, Skoog I. The Gothenburg H70 Birth Cohort Study 2014-16: design, methods and study population. European Journal of Epidemiology 2019; 34(2): 191-209. *TRS and FA are joint first authors. http://doi.org/10.1007/s10654-018-0459-8en
dc.relation.haspartII. Ahlner F, Sigström R, Rydberg Sterner T, Mellqvist Fässberg M, Kern S, Östling S, Waern M, Skoog I. Increased alcohol consumption among Swedish 70-year-olds 1976 to 2016: Analysis of data from The Gothenburg H70 Birth Cohort Studies, Sweden. Alcoholism: Clinical and Experimental Research 2018; 42(12): 2403-2412. http://doi.org/10.1111/acer.13893en
dc.relation.haspartIII. Ahlner F, Falk Erhag H, Johansson L, Mellqvist Fässberg M, Rydberg Sterner T, Samuelsson J, Zettergren A, Waern M, Skoog I. Patterns of alcohol consumption and associated factors in a population-based sample of 70-year-olds: Data from the Gothenburg H70 Birth Cohort Study 2014-16. International Journal of Environmental Research and Public Health 2022; 19(14): 8248. http://doi.org/10.3390/ijerph19148248en
dc.relation.haspartIV. Ahlner F, Falk Erhag H, Johansson L, Samuelsson J, Wetterberg H, Mellqvist Fässberg M, Waern M, Skoog I. The effect of alcohol consumption on all-cause mortality in 70-year-olds in the context of other lifestyle risk factors: Results from The Gothenburg H70 Birth Cohort Study. (Submitted)en
dc.subjectseptuagenarianen
dc.subjectageden
dc.subjectalcohol consumptionen
dc.subjectdrinking behavioren
dc.subjectrisk consumptionen
dc.subjectcohort studiesen
dc.subjectassociated factorsen
dc.subjectlongitudinal studiesen
dc.subjectpublic healthen
dc.subjectepidemiologyen
dc.titleAlcohol use among older adults: Population perspectives on prevalence, correlates, and consequences of drinking in Swedish 70-year-oldsen
dc.typetexteng
dc.type.svepDoctoral thesiseng
dc.gup.mailfelicia.ahlner@gu.seen
dc.type.degreeDoctor of Philosophy (Medicine)en
dc.gup.originUniversity of Gothenburg. Sahlgrenska Academyen
dc.gup.departmentInstitute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistryen
dc.gup.defenceplaceOnsdagen den 17 maj 2023, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg https://gu-se.zoom.us/j/62520412170?pwd=TDFhSExHQkJqMmFOeUpZNGpBSmRKZz09en
dc.gup.defencedate2023-05-17
dc.gup.dissdb-fakultetSA


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