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Early stage inflammation and cancer as reflected in the gastrointestinal mucus composition: implications for diagnosis, prognosis and pathogenesis


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Title: Early stage inflammation and cancer as reflected in the gastrointestinal mucus composition: implications for diagnosis, prognosis and pathogenesis
Authors: Sjöberg Jabbar, Karolina
E-mail: karolina.sjoberg@medkem.gu.se
Issue Date: 23-Oct-2018
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Biochemistry and Cell Biology
Parts of work: I. Jabbar KS, Verbeke C, Hyltander AG, Sjövall H, Hansson GC, Sadik R. Proteomic mucin profiling for the identification of cystic precursors of pancreatic cancer. J Natl Cancer Inst. 2014;106(2): djt439.
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II. Jabbar KS, Arike L, Verbeke CS, Sadik R, Hansson GC. Highly accurate identification of cystic precursor lesions of pancreatic cancer through targeted mass spectrometry: a phase IIc diagnostic study. J Clin Oncol. 2018; 36(4): 367–375.
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III. van der Post S*, Jabbar KS*, Birchenough GMH, Arike L, Akhtar N, Sjövall H, Johansson MEV, Hansson GC. Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis. Submitted.

IV. Jabbar KS, van der Post S, Johansson MEV, Hansson GC. The protein composition of the colonic mucus barrier predicts disease course in ulcerative colitis patients. Manuscript.

V. Jabbar KS, Dolan B, Eklund L, Wising C, Ermund A, Johansson Å, Törnblom H, Simrén M*, Hansson GC*. The presence of Brachyspira species in the colonic epithelium and inner mucus layer may be linked to disease development in up to a third of IBS patients. Manuscript.
Date of Defence: 2018-11-12
Disputation: Måndagen den 12 november 2018, kl. 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Mucus
Mass spectrometry
MUC2
MUC5AC
IPMN
Pancreatic cysts
Ulcerative colitis
IBS
Brachyspira
Abstract: Mucus covers our inner interfaces towards the environment, providing protection while enabling vital interaction with the outside world. The mucus is built around mucin proteins, which are important for our defences against infection and inflammation, but may also contribute to carcinogenesis and tumour progression. These divergent aspects of mucin biology are exemplified in the different studies in this thesis, which are all based on mass spectrometry. The topics covered range from mucin biomar... more
ISBN: 978-91-7833-128-4 (PDF)
URI: http://hdl.handle.net/2077/56912
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

 

 

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