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Central actions of glucagon-like peptide-1 on food intake and reward: Novel neurological targets and sex divergent effects
(2019-12-06)
Obesity is one of the biggest health risks of our society; however, treatment options are sparse and often result in suboptimal weight-loss. The glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonist liraglutide was ...
Taurine and dopamine-related effects of ethanol. An experimental study in rodents
(2019-11-18)
The reinforcing properties of alcohol (ethanol) are associated with activation of the mesolimbic dopamine system and the concomitant increase in dopamine in the nucleus accumbens (nAc). Changes in this system are thought ...
In vitro models of the blood brain-barrier using iPSC-derived cells
(2019-11-18)
immortalized brain endothelial cell lines and primary brain endothelial cells of human and animal origin. Unfortunately, these cell lines and primary cells have failed to recreate physiologically relevant control of transport in vitro. Human-induced pluripotent...
The gut-brain axis and alcohol-mediated behaviours: the amylin story
(2019-10-29)
Alcohol use disorder (AUD) is a complex neuropsychiatric disorder with high rates of
mortality and morbidity. The currently available pharmacotherapies show varied
efficacy, leading to the investigation of new neurochemical ...
Surgical and neurological adverse effects of epilepsy surgery
(2019-10-16)
The aim of this thesis was to study surgical and neurological complications of preoperative invasive investigations and epilepsy surgery procedures (Papers I-II) and seizure worsening after epilepsy surgery (Paper III). A ...
Participation after stroke in a short- and long-term perspective
(2019-10-15)
The main scope of this thesis was to study and describe perceived participation among persons with stroke. In doing so, different timepoints were chosen to make a more complete picture of participation after stroke. The ...
Neurofilaments as biomarkers of neuronal damage
(2019-09-24)
Different neurodegenerative diseases have overlapping symptomatology and pathology and have thus become a challenge to modern medicine to achieve a correct diagnosis. The aim of the thesis was to evaluate the use of ...
Adipose tissue mitchondrial function is modulated by antioxidants
(2019-09-23)
Antioxidants are widely used as reactive oxygen species (ROS) scavenging
agents in experimental research and in conditions where oxidative stress
plays a primary role. However, the effect of antioxidant supplementation ...
Generalized anxiety disorder (GAD) and anxiety symptoms in older adults
(2019-09-11)
Anxiety is a broad concept, difficult to detect and recognize. Expression may shift over the lifetime further complicating identification. Generalized Anxiety Disorder (GAD) is one of the most common anxiety disorders in ...
Tau fragments: role as biomarkers and in the pathogenesis of Alzheimer's disease and other tauopathies
(2019-09-10)
N-123 is part of the physiological tau turnover, the generation of tau N-224 was shown to have clinical relevance, being related to AD; N-224 tau showed significantly higher concentrations in AD CSF compared to control and was related to worsening...