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Preclinical investigations of GlyT-1 inhibition as a new concept for treatment of alcohol dependence
(2011-02-02)
Alcohol addiction and abuse is a main contributor to the global burden of disease and is a high public health priority. Alcohol addiction is a chronically relapsing neurobiological disorder affecting multiple neurotransmitter ...
The cholinergic-dopaminergic reward link and addictive behaviours: special emphasis on ethanol and ghrelin
(2007-05-16)
An important part of the reward systems is the cholinergic-dopaminergic reward link. This reward link has been proposed to be involved in reward and motivated behaviours. It encompasses a cholinergic input from the ...
Glycine receptors in the central nervous system - development, distribution and relation to actions of alcohol
(2012-11-14)
The widespread consumption of alcohol and the great socioeconomic impact of alcohol abuse and addiction have contributed to the extensive investigations of this substance. Despite great efforts there is still uncertainty ...
Conditional and non-conditional reward-related responses to alcohol - nicotinic mechanisms
(2006-11-14)
The mesolimbic dopamine system is believed to mediate the positive reinforcing and rewarding effects of addictive drugs by increasing dopamine levels in its terminal area, the nucleus accumbens (nAc). Nicotinic acetylcholine ...