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The susceptibility to metabolic and proliferative diseases - from genetic predisposition to treatment
(2014-05-05)
Obesity and type 2 diabetes increase the risk of cardiovascular disease. Insulin resistance is highly correlated to type 2 diabetes and both obesity and insulin resistance are risk factors for cancer. Bariatric surgery is ...
Hutchison-Gilford Progeria Syndrome – A new treatment strategy and the role of prelamin A in oncogenesis
(2014-04-25)
Prelamin A, a CaaX-protein is a key structural protein of the inner nuclear lamina, a meshwork lining the inner
nuclear envelope. Farnesylated prelamin A is cleaved just upstream of the farnesylcysteine residue to ...