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Gut microbial regulation of bile acid metabolism and signaling


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Title: Gut microbial regulation of bile acid metabolism and signaling
Authors: Sayin, Sama
E-mail: sama.sayin@wlab.gu.se
Issue Date: 25-Jan-2016
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Molecular and Clinical Medicine
Parts of work: I. Sayin SI et al. Gut microbiota regulates bile acid metabolism by reducing levels of tauro-beta-muricholic acid, a naturally occuring FXR antagonist. Cell Metab 2013;17:225-235.
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II. Sayin et al. Differential FXR-mediated regulation by the gut microbiota in the liver and the intestine. In Manuscript
Date of Defence: 2016-02-12
Disputation: Fredagen den 12 februari 2016, kl. 13.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Medicine
Gut Microbiota
Bile Acids
Abstract: The collection of microbes in our gastrointestinal tract, the gut microbiota, is an environmental factor that has profound impact on host health and disease. Bile acids are endogenous cholesterol-derived molecules that can be modified by the gut microbiota and function as signaling molecules in regulation of host metabolic processes. This thesis investigates the role of the gut microbiota on bile acid metabolism and signaling by comparing mice that lack microbiota with their conventionally-raise... more
ISBN: 978-91-628-9703-1 (PDF)
978-91-628-9702-4 (Print)
URI: http://hdl.handle.net/2077/40886
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin

 

 

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