Browsing Doctoral Theses from Sahlgrenska Academy by Title
Now showing items 1933-1952 of 2013
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Ulcerative Colitis - Surgery Outcome and Pathophysiological Aspects
(2014-03-14)Background: Ulcerative Colitis (UC) is a chronic inflammatory bowel disease; the etiology is mainly unknown. Around 30% of the patients are treated by surgery. The aims of this thesis were to evaluate outcome after specific ... -
Ultrasensitive DNA sequencing using liquid biopsies enables precision medicine
(2021-03-18)Liquid biopsies are minimally invasive and allow repetitive sampling of body fluids. Analysis of cell-free tumor DNA in liquid biopsies can be used as a biomarker for cancer. However, in most clinically relevant liquid ... -
Ultrasonography for Diagnosis, Intervention and Follow-up in Juvenile Idiopathic Arthritis
(2011-11-25)Early therapeutic intervention and the use of novel, highly effective treatments in juvenile idiopathic arthritis (JIA) have improved the outcome in many diseased children, but have also increased the need for more precise ... -
Ultrasound assessment of carotid atherosclerosis focusing on plaque characteristics and changes over time
(2011-05-26)In a clinical perspective better methods to identify subjects at increased cardiovascular risk are needed. Atherosclerotic plaques of the carotid arteries with low echogenicity have been related to future clinical events. ... -
Ultrasound evaluation of atherosclerosis and other cardiovascular sources of cerebral embolism
(2008-01-18)The search for embolic sources has high priority in patients presenting with suspected cerebral embolism. Non-invasive cardiovascular ultrasound is frequently used to reveal the presence of carotid stenosis and cardiac ... -
Ultrasound measurement of cervical length in the second trimester of pregnancy for prediction of preterm delivery
(2019-05-07)Abstract Background: Short cervical length is a risk factor for preterm delivery (PTD) and screening of cervical length using transvaginal ultrasound in the second trimester is a proposed method to find women at risk Aims: ... -
Understanding normal-tissue late effects in the intestines after pelvic radiotherapy
(2020-04-02)Radiotherapy cures patients from deadly cancer, alone or in combination with other treatments. The photons must pass through normal tissue to converge on the tumor, and it is unavoidable that radiotherapy causes acute as ... -
Understanding the molecular mechanisms of bile acid receptor activation for the treatment of human liver disease
(2020-04-30)Farnesoid X receptor (FXR) is a nuclear transcription factor that is activated by bile acids and regulates bile acid homeostasis, glucose and lipid metabolism. FXR activation by a ligand has been identified as a therapeutic ... -
Understanding the regulatory requirements for gut IgA B cell responses and their potential role in mucosal vaccine development
(2018-05-28)It is important to understand gut B cell differentiation, from the activation of cells at inductive lymphoid sites to the formation of gut plasma and memory B cell, to be able to develop efficient oral vaccines but the ... -
Understanding the role of long non-coding RNAs in neuroblastoma development and progression
(2019-11-11)Neuroblastoma (NB), a common cancer of childhood, contributes to 15% of all pediatric cancer deaths. The improper neuronal differentiation of neural crest cells to mature neurons in the sympathetic nervous system leads to ... -
Unexpected salivary secretory effects of some atypical antipsychotics - preclinical studies on clozapine, N-desmethylclozapine, amisulpride and olanzapine
(2013-04-29)Antipsychotics are generally associated with dry mouth and deterioration of the oral health. However, clozapine, the archetype of the atypical antipsychotics, is reported to induce not only mouth dryness but also, in about ... -
Unexplained chest pain in men and women - symptom perception and outcome
(2009-01-30)Patients with chest pain account for a large number of all patients seeking health care. The majority of these patients are referred to emergency departments (ED) and many of them are given a discharge diagnosis of unexplained ... -
Ungdomars och deras föräldrars erfarenheter av att leva med inflammatorisk tarmsjukdom – Fokus på hälsa, självkänsla och egenvård
(2010-05-17)Abstract Inflammatory bowel disease (IBD) is a chronic and relapsing disorder of the gastrointestinal tract that includes the two major subcategories ulcerative colitis and Crohn´s disease. Suffering from IBD during ... -
Unmet need for mental healthcare among men Sweden: Gendered pathways to care
(2022-02-02)Aim: Depression and anxiety disorders have a lifetime prevalence of about 10% among men in high-income countries but many do not seek and receive the care that they need. The aim of this thesis was to explore gendered ... -
Unravelling the duality of Caregivinghood - How informal caregivers describe their situation when salutogenically approached
(2017-05-12)Demographic changes and an emphasis on community care, increase the number of informal caregivers to older adults in most societies. Their willingness to provide care and that they are healthy enough to manage, is essential. ... -
Unravelling the mechanisms for mucosal tolerance induction using the CTA1R7K-X-DD immunomodulating fusion protein
(2016-11-11)Unravelling the mechanisms for mucosal tolerance induction using the CTA1R7K-X-DD immunomodulating fusion protein: Effective treatment options against autoimmune diseases Tolerance is a physiological mechanism that ... -
Upper and Lower Motoneuron Lesions in Tetraplegia - Diagnostic and Therapeutic Implications of Electrical Stimulation
(2019-09-25)The overall objective of this thesis was to improve outcomes and predictability of the treatment of upper extremity function in patients with cervical spinal cord injury and tetraplegia by advancing the diagnostic and ... -
Upper extremity functioning during the first year after stroke
(2015-12-17)The overall aim of this thesis was to investigate upper extremity functioning during the first year after stroke from different perspectives. Methods. All patients with first ever stroke, admitted to a stroke unit within ... -
Upplevelse och lindring av fatigue och gastrointestinala symtom - hos patienter som genomgår strålbehandling
(2012-09-12)Despite an extensive literature on cancer-related fatigue, there are still gaps in knowledge concerning its development and alleviation. The overall aim of this thesis was to explore symptom experiences and self-care ... -
Urethral strictures in men: Studies on reconstructive surgery and pathophysiology
(2016-11-14)Urethral stricture is a common disease that is characterised by fibrotic tissue arising from inflammation after urethral injury. Urination is inhibited when there is total obstruction, and the suffering is immense. Following ...