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Understanding normal-tissue late effects in the intestines after pelvic radiotherapy

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Title: Understanding normal-tissue late effects in the intestines after pelvic radiotherapy
Authors: Malipatlolla, Dilipkumar
Issue Date: 2-Apr-2020
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clinical Sciences. Department of Oncology
Parts of work: I. Bull C, Malipatlolla D, Kalm M, Sjöberg F, Alevronta E, Grandér R, Sultanian P, Persson L, Boström M, Eriksson Y, Swanpalmer J, Wold AE, Blomgren K, Björk-Eriksson T, Steineck G. A novel mouse model of radiation-induced cancer survivorship diseases of the gut. Am J Physiol Gastrointest liver physiol. 2017 Nov 1; 313(5): G456-G466.

II. Dilip K Malipatlolla, Piyush Patel, Fei Sjöberg, Sravani Devarakonda, Marie Kalm, Eva Angenete, Elinor Bexe Lindskog, Rita Grandér, Linda Persson, Andrea Stringer, Ulrica Wilderäng, John Swanpalmer, Hans Georg Kuhn, Gunnar Steineck, Cecilia Bull. Long-term mucosal injury and repair in a murine model of pelvic radiotherapy. Sci Rep. 2019; 9:13803.

III. Malipatlolla DK, Piyush Patel, Sravani Devarakonda, Jolie Danial, Eva Mehdin, Henrietta Norling, Malin Warholm, Rita Grandér, Margareta Nyman, Ana Rascon, Andrea Stringer, Fei Sjöberg, Marie Kalm, Gunnar Steineck, Cecilia Bull. A fiber-rich diet and persistent pathophysiological processes in the irradiated intestines. (Manuscript).

IV. Patel P, Malipatlolla DK, Devarakonda S, Bull C, Rascon A, Nyman M, Stringer A, Steineck G, Sjöberg F. Oat bran fiber reduces systemic inflammation in mice subjected to pelvic irradiation. (Manuscript).
Date of Defence: 2020-04-23
Disputation: Torsdagen den 23 April 2020, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Pelvic radiotherapy
Intestinal inflammation
dietary fiber
Abstract: Radiotherapy cures patients from deadly cancer, alone or in combination with other treatments. The photons must pass through normal tissue to converge on the tumor, and it is unavoidable that radiotherapy causes acute as well as late adverse effects. Roughly one million cancer survivors in Europe are suffering from radiation-induced intestinal symptoms, such as urgency to defecate, leakage of feces and mucus, bleeding, and excessive odorous gas discharge. The symptoms can appear weeks to years a... more
ISBN: 978-91-7833-829-0 (PDF)
978-91-7833-828-3 (PRINT)
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper



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