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Clinical Outcome and Prognostic Factors in Borderline Ovarian Tumors and Invasive Ovarian Carcinomas in Western Sweden
(2008-11-24)
Ovarian cancer, the most lethal of gynecological malignancies in Sweden, is first diagnosed in advanced stages in two thirds of the cases. Although the incidence is decreasing, mortality remains high.
Clinical guidelines ...
Development of targeted alpha therapy with Bi-213 and At-211 for the treatment of disseminated cancer
(2016-03-01)
Radioimmunotherapy (RIT) is a type of targeted cancer therapy. The concept behind RIT is to deliver cytotoxic ionizing radiation to tumor cells by attaching radionuclides to tumor-specific antibodies. The radioimmunoconjugates ...
Characterization of genetic alterations in ovarian cancer associated with chemotherapy response
(2009-05-13)
Ovarian cancer is the most lethal of all gynecological malignancies, and exhibit an overall fiveyear
survival rate of only 48% in Sweden. The high mortality in ovarian cancer is largely due to
late diagnosis and chemotherapy ...
Pharmacokinetics and dosimetry in intraperitoneal radioimmunotherapy with 211At
(2014-03-24)
The prognosis for patients diagnosed with disseminated cancer is often poor.
Radioimmunotherapy (RIT) is a new approach to treat disseminated disease.
The aim is to target tumor cells with monoclonal antibodies (mAbs) ...
The effect of intra-abdominal local anaesthetics following major gynaecological surgery. Clinical and experimental studies
(2020-05-18)
Background: Local anaesthetics (LA), in addition to inhibition of pain signalling, also have anti-inflammatory
properties. In vitro studies have demonstrated anti-proliferative and cytotoxic effect of
LAs on cancer cells ...
Pretargeting agents and At-211-labeled effector molecules: Synthesis and preclinical evaluation for pretargeted alpha-radioimmunotherapy.
(2012-05-15)
Targeted therapies are treatment regimens in which tumor specific substances incorporating some sort of cell-killing effect are administered to patients. For cancer therapy they have emerged as a means of preventing ...