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|Title:||The Relationship between Transmembrane Mucins, Ion Channels and PDZ Adaptor Proteins in the Small Intestine|
|University:||University of Gothenburg. Sahlgrenska Academy|
|Institution:||Institute of Biomedicine. Department of Medical Biochemistry and Cell Biology|
|Parts of work:||I. Malmberg, E. K., Pelaseyed, T., Petersson, A. C., Seidler, U. E., De Jonge, H., Riordan, J. R. and Hansson, G. C. (2008) The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine. Biochem. J. 410, 283-289|
II. Pelaseyed, T. and Hansson, G. C. (2011) CFTR anion channel modulates expression of human transmembrane mucin MUC3 through the PDZ protein GOPC. J. Cell. Sci. 124, 3074-3083
III. Pelaseyed, T., Zäch, M., Petersson, Å. C., Svensson, F., Johansson, D.G.A., Hansson, G. C. Unfolding dynamics of the mucin SEA domain probed by force spectroscopy suggest that it acts as a cell protective device. Submitted.
IV. Pelaseyed, T., Gustafsson, J. K., Gustafsson, I. J., Hansson, G. C Carbacholinduced internalization of human transmembrane MUC17 mucin is concomitant with NHE3 internalization and CFTR externalization in enterocytes. Manuscript.
|Date of Defence:||2012-11-16|
|Disputation:||Fredagen den 16 november 2012, kl 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg|
|Degree:||Doctor of Philosophy (Medicine)|
|Publication type:||Doctoral thesis|
|Abstract:||The human body is continuously exposed to challenges from the surrounding world. In analogy with the skin, mucus is a well-organized and highly regulated barrier composed of polymeric and O-glycosylated mucins that protects luminal organs such as the gastrointestinal tracts from the outer milieu. As part of a first defensive barrier, the secreted mucins entrap pathogens and act as a network for antiseptic enzymes and proteins. A second barrier is the dense glycocalyx which is composed of tr... more|
|Appears in Collections:||Doctoral Theses from Sahlgrenska Academy|
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin
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