Sahlgrenska Academy / Sahlgrenska akademin >
Institute of Biomedicine / Institutionen för biomedicin >
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin >

The Relationship between Transmembrane Mucins, Ion Channels and PDZ Adaptor Proteins in the Small Intestine

Please use this identifier to cite or link to this item:

Files in This Item:

File Description SizeFormat
gupea_2077_29724_1.pdfThesis frame5608KbAdobe PDF
gupea_2077_29724_5.pdfAbstract230KbAdobe PDF
Title: The Relationship between Transmembrane Mucins, Ion Channels and PDZ Adaptor Proteins in the Small Intestine
Authors: Pelaseyed, Thaher
Issue Date: 26-Oct-2012
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Biochemistry and Cell Biology
Parts of work: I. Malmberg, E. K., Pelaseyed, T., Petersson, A. C., Seidler, U. E., De Jonge, H., Riordan, J. R. and Hansson, G. C. (2008) The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine. Biochem. J. 410, 283-289

II. Pelaseyed, T. and Hansson, G. C. (2011) CFTR anion channel modulates expression of human transmembrane mucin MUC3 through the PDZ protein GOPC. J. Cell. Sci. 124, 3074-3083

III. Pelaseyed, T., Zäch, M., Petersson, Å. C., Svensson, F., Johansson, D.G.A., Hansson, G. C. Unfolding dynamics of the mucin SEA domain probed by force spectroscopy suggest that it acts as a cell protective device. Submitted.

IV. Pelaseyed, T., Gustafsson, J. K., Gustafsson, I. J., Hansson, G. C Carbacholinduced internalization of human transmembrane MUC17 mucin is concomitant with NHE3 internalization and CFTR externalization in enterocytes. Manuscript.
Date of Defence: 2012-11-16
Disputation: Fredagen den 16 november 2012, kl 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: intestine
Abstract: The human body is continuously exposed to challenges from the surrounding world. In analogy with the skin, mucus is a well-organized and highly regulated barrier composed of polymeric and O-glycosylated mucins that protects luminal organs such as the gastrointestinal tracts from the outer milieu. As part of a first defensive barrier, the secreted mucins entrap pathogens and act as a network for antiseptic enzymes and proteins. A second barrier is the dense glycocalyx which is composed of tr... more
ISBN: 978-91-628-8521-2
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin



© Göteborgs universitet 2011