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The Relationship between Transmembrane Mucins, Ion Channels and PDZ Adaptor Proteins in the Small Intestine


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Title: The Relationship between Transmembrane Mucins, Ion Channels and PDZ Adaptor Proteins in the Small Intestine
Authors: Pelaseyed, Thaher
E-mail: thaher.pelaseyed@medkem.gu.se
Issue Date: 26-Oct-2012
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Medical Biochemistry and Cell Biology
Parts of work: I. Malmberg, E. K., Pelaseyed, T., Petersson, A. C., Seidler, U. E., De Jonge, H., Riordan, J. R. and Hansson, G. C. (2008) The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine. Biochem. J. 410, 283-289
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II. Pelaseyed, T. and Hansson, G. C. (2011) CFTR anion channel modulates expression of human transmembrane mucin MUC3 through the PDZ protein GOPC. J. Cell. Sci. 124, 3074-3083
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III. Pelaseyed, T., Zäch, M., Petersson, Å. C., Svensson, F., Johansson, D.G.A., Hansson, G. C. Unfolding dynamics of the mucin SEA domain probed by force spectroscopy suggest that it acts as a cell protective device. Submitted.

IV. Pelaseyed, T., Gustafsson, J. K., Gustafsson, I. J., Hansson, G. C Carbacholinduced internalization of human transmembrane MUC17 mucin is concomitant with NHE3 internalization and CFTR externalization in enterocytes. Manuscript.
Date of Defence: 2012-11-16
Disputation: Fredagen den 16 november 2012, kl 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: intestine
mucin
MUC3
MUC17
SEA
PDZK1
GOPC
CFTR
NHE3
Abstract: The human body is continuously exposed to challenges from the surrounding world. In analogy with the skin, mucus is a well-organized and highly regulated barrier composed of polymeric and O-glycosylated mucins that protects luminal organs such as the gastrointestinal tracts from the outer milieu. As part of a first defensive barrier, the secreted mucins entrap pathogens and act as a network for antiseptic enzymes and proteins. A second barrier is the dense glycocalyx which is composed of tr... more
ISBN: 978-91-628-8521-2
URI: http://hdl.handle.net/2077/29724
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

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