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Multi-level characterization of host and pathogen in Helicobacter pylori-associated gastric carcinogenesis
Today, more than half of the world’s population is infected with Helicobacter pylori, and two to three per cent of these will develop gastric cancer associated with this infection. Gastric cancer is today the third largest ...
The susceptibility to metabolic and proliferative diseases - from genetic predisposition to treatment
Obesity and type 2 diabetes increase the risk of cardiovascular disease. Insulin resistance is highly correlated to type 2 diabetes and both obesity and insulin resistance are risk factors for cancer. Bariatric surgery is ...
Hutchison-Gilford Progeria Syndrome – A new treatment strategy and the role of prelamin A in oncogenesis
Prelamin A, a CaaX-protein is a key structural protein of the inner nuclear lamina, a meshwork lining the inner nuclear envelope. Farnesylated prelamin A is cleaved just upstream of the farnesylcysteine residue to ...