Bronchopulmonary dysplasia (BPD) is a major cause of mortality and long-term morbidity in prematurely born infants. Pulmonary inflammation, and abnormal alveolar and vascular development of the lung are histological ...

The use of transplantation to enhance quality of life is a growing clinical field that also includes transplantation of reproductive organs. Transplantation of the uterus has been suggested as future method to treat uterus ...

The aim of this thesis was to investigate if and how insulin antagonizes interleukin-6 (IL-6)-signaling and action using both 3T3-L1 mouse adipocytes (Paper I) and HepG2 human hepatocytes (Paper III). We also investigated ...

Invasive growth of malignant tumors is associated with local and systemic inflammation, which may promote progression and metastases. Inflammation is also responsible for appearing manifestations of advanced cancer as ...

Background: Obesity is associated with disturbances in cardiovascular structure and function varying along with the degree of fatness, but the mechanisms underlying this co-variation are unclear. Short-term weight loss ...

Type 2 diabetes (T2D) and the metabolic syndrome (MetS), two conditions that are rapidly increasing in prevalence, as well as the dyslipoproteinemia and subclinical inflammation characteristic for these conditions, are ...

Inflammation alters the functional properties of the urinary bladder. Interstitial cystitis (IC) is a chronic inflammatory syndrome in man that is characterized by urgency, frequency and visceral pain. The overall aim of ...

S100A4 belongs to the family of calcium-binding S100 proteins and modulates cell proliferation, cytoskeletal rearrangement, cell motility, and angiogenesis. Increased levels of S100A4 expression correlate with high ...

Eosinophilic Esophagitis (EoE) is a chronic inflammatory disorder of unknown etiology, in which the esophagus is infiltrated by eosinophils and T cells. Topical corticosteroids are one of the treatment options for patients ...

Diesel engine exhaust is a complex mixture of gaseous and particulate compounds produced during the combustion of diesel fuels. The gas phase includes carbon dioxide, nitrogen oxides (NOX), carbon monoxide and small amounts ...