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Now showing items 2611-2620 of 2863
Investigations into the role of Epstein-Barr virus in the pathogenesis of multiple sclerosis
(2022-09-08)
Epstein-Barr virus (EBV) infection may be a prerequisite for the development of MS.
Virtually all MS patients have antibodies to Epstein Barr virus nuclear antigen 1
(EBNA1), compared to 90-95% of healthy individuals. ...
Valvular aortic stenosis in children. Outcome, physical activity and health-related quality of life
(2022-04-11)
Introduction: Isolated valvular aortic stenosis (VAS) accounts for 3–5% of congenital heart disease and presents with a wide spectrum of severity. Critical VAS in the neonate is the most severe form, fatal in the absence ...
Vaccine responses after chemotherapy or stem cell transplantation in patients with hematological malignancies
(2022-09-22)
The prevention of infections in patients with hematological malignancies is important given the inherent immune deficiency associated with these diseases and the immunosuppressive effects of treatment. This thesis investigated ...
Free Fatty Acid Receptor 2 - A G protein coupled receptor with unique signaling properties in neutrophils
(2022-08-15)
The overall aim of the PhD thesis was to determine the role of neutrophil pattern recognition receptors in the initiation and resolution of inflammatory processes. Neutrophil pattern recognition receptors such as the formyl ...
The use of immunological biomarkers to improve individualization of postoperative radiotherapy in breast cancer
(2022-09-30)
Radiotherapy (RT) forms the cornerstone of most curative breast cancer treatment due to its well-established risk-reducing effect on local recurrences at the population level. However, there is heterogeneity regarding ...
Oral eflornithine treatment of late-stage human African trypanosomiasis
(2022-11-21)
Human African trypanosomiasis is a fatal disease unless treated. It is a parasitic vector borne disease endemic in sub-Saharan African countries. Eflornithine is a recommended treatment for gambiense human African ...
Dietary quality, greenhouse gas emissions related to food consumption, and human health: A population-based cohort study in northern Sweden
(2022)
The overall aim of this thesis was to assess dietary quality and dietary-related greenhouse gas emissions (GHGEs), and their association with health outcomes, in a population-based cohort in northern Sweden.
Dietary data ...
Mechanical circulatory support in advanced heart failure - patient selection, treatment strategies and outcomes
(2022-09-19)
Background: Heart transplantation (HTx) remains the major treatment option for selected
patients with end-stage heart failure. In hemodynamically unstable patients, or when there is a
considerable risk of deterioration ...
3D Printed scaffolds as cancer microenvironment medels for drug discovery
(2022-04-05)
Cancer is one of the most common diseases in the modern world and major efforts are made globally to develop new diagnostics and treatments. It originates from a cell which, at some point, has begun to divide and grow ...
Rehabilitation and outcomes after spasticity-correcting surgery in the upper limb
(2022-09-09)
Background: The ability to perform everyday life activities is beneficial for one’s self-identity and contributes to human well-being. Enhancement of activity performance is therefore central in all forms of rehabilitation. ...