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Now showing items 131-140 of 149
Long-gap esophageal atresia - The development of an experimental model of esophageal regeneration in vivo as an attempt to improve clinical outcome
(2015-01-07)
Background: A subset (~8-15%) of the patients born with esophageal atresia (EA) suffer from a lack of esophageal tissue, which makes a primary anastomosis difficult to achieve. This is most common in patients born without ...
Human adipose tissue morphology and function : relation to insulin sensitivity and glucose tolerance with focus on pregnancy and women with previous gestational diabetes mellitus
(2015-10-23)
Obesity is a global health problem and affects women of reproductive age. During pregnancy, obesity increases the risk for gestational diabetes mellitus (GDM), in turn predisposing for type 2 diabetes (T2D). Not only the ...
Prediagnostic and comorbidity factors in preschool children with autism
(2015-08-31)
The aim of the thesis was to investigate Autism Spectrum Disorder (ASD) diagnosed in the early
years from different angles; screening, load of coexisting disorders, outcome at routine
developmental surveillance, and to ...
Impact of Host Genetic Variants on Natural History and Treatment of Hepatitis C Virus Infection
(2015-01-30)
Chronic hepatitis C Virus (HCV) infection causes liver disease and may progress to severe fibrosis, cirrhosis, and hepatocellular carcinoma. This thesis aimed to evaluate the impact of host genetics, i.e. genetic variants ...
Measurement of T1 relaxation time in lungs - Preclinical and clinical MRI applications to COPD
(2015-09-16)
Monitoring of regional lung function in clinical trials of chronic obstructive pulmonary disease (COPD) requires alternative endpoints beyond global pulmonary function tests (PFTs), which is the most common approach for ...
Pharmacokinetics of artemisinin derivatives in rats, healthy volunteers and patients
(2015-09-04)
Malaria is still a major health problem, killing approximately 1,600 people each day. The most vulnerable patient groups are children under the age of five and pregnant women. Artemisinin-based combination therapy is ...
Peri-implantitis and periodontitis. Experimental and clinical studies
(2015-03-24)
Peri-implantitis is an increasing problem in implant dentistry. The current series of studies employed a translational approach with the aim to compare peri-implantitis and periodontitis lesions and evaluate the influence ...
Studies on carotid plaque vulnerability using contrast enhanced ultrasound
(2015-10-14)
ABSTRACT
Background and Aim: Contrast-enhanced ultrasound is a method to examine neovessels that may be present inside the atherosclerotic plaque of the carotid arteries. These neovessels are believed to be involved in ...
On HIV-1 latency and viral reservoirs
(2015-05-11)
HIV-1 establishes a latent infection that is inaccessible to treatment in cellular and
anatomical reservoirs. This thesis concerns several problematic issues of HIV-1
persistence, including ways to measure and monitor ...
Laparoscopic surgery as treatment for rectal cancer
(2015-05-11)
Introduction
Colorectal cancer is the third most common cancer worldwide, with nearly 1.4 million new cases annually, of which
about one third suffer from rectal cancer. Laparoscopic surgery has in several surgical fields ...