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Human adipose tissue morphology and function : relation to insulin sensitivity and glucose tolerance with focus on pregnancy and women with previous gestational diabetes mellitus


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Title: Human adipose tissue morphology and function : relation to insulin sensitivity and glucose tolerance with focus on pregnancy and women with previous gestational diabetes mellitus
Authors: Svensson, Henrik
E-mail: henrik.svensson@clinchem.gu.se
Issue Date: 23-Oct-2015
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Biomedicine. Department of Clinical Chemistry and Transfusion Medicine
Parts of work: Svensson H, Odén B, Edén S, and Lönn M Adiponectin, chemerin, cytokines and dipeptidyl peptidase 4 are released from human adipose tissue in a depot-dependent manner: an in vitro system including human serum albumin BMC Endocrine Disorders. 2014; 14:7
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Svensson H, Wetterling L, Odén B, Odén A, Jennische E, Edén S, Holmäng A, and Lönn M Body fat mass and the proportion of very large adipocytes in pregnant women are associated with gestational insulin resistance Submitted manuscript

Svensson H, Wetterling L, Odén A, Jennische E, Edén S, Holmäng A and, Lönn M BMI, waist-to-height ratio and adipocyte volume are associated with impaired glucose metabolism and insulin resistance in women with previous gestational diabetes: A 6-year follow-up study Submitted manuscript
Date of Defence: 2015-11-05
Disputation: Torsdagen den 5 november 2015, kl 9.00, Hörsal Sahlgrens aula, Sahlgrenska sjukhuset, Blå stråket 5, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Adipose tissue
Adipocyte
Adipokines
Insulin resistance
Pregnancy
Gestational diabetes mellitus
Type 2 diabetes
Abstract: Obesity is a global health problem and affects women of reproductive age. During pregnancy, obesity increases the risk for gestational diabetes mellitus (GDM), in turn predisposing for type 2 diabetes (T2D). Not only the amount and distribution of adipose tissue (AT) but also the AT morphology and function are of importance in pathogenesis of metabolic disease related to obesity. The aims of this thesis were 1) to compare subcutaneous (SC) and visceral AT regarding release of adipokines, implica... more
ISBN: 978-91-628-9568-6 (PDF)
978-91-628-9567-9 (print)
URI: http://hdl.handle.net/2077/39574
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för biomedicin

 

 

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