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Now showing items 1381-1390 of 1393
Inhibition of HIV-1 and HSV-2 infection by glycosaminoglycan mimetics
(2013-10-08)
HIV-1 is a sexually transmitted pandemic pathogen that causes progressive defects in cell-mediated immunity for which curative treatment and prophylaxis are lacking. In addition to CD4 and chemokine receptors of protein ...
Mechanisms for and consequences of cellular lipid accumulation - Role of the Very Low Density Lipoprotein (VLDL) receptor
(2011-12-02)
Lipid accumulation in non adipose tissue is associated with various cases of tissue dysfunction and tissue failure. Reduced availability of oxygen is known to cause intracellular lipid accumulation in cardiomyocytes as ...
WISP-2 - A Novel Adipokine Related to Obesity and Insulin resistance
(2015-02-27)
Type 2 diabetes mellitus (T2D) is increasing worldwide at an epidemic rate and is expected to reach 592 million inflicted individuals by 2035 as compared to 382 million in 2013. Obesity is a major risk factor for insulin ...
Lactobacilli in the normal microbiota and probiotic effects of Lactobacillus plantarum
(2010-01-11)
Lactobacilli colonise most adult individuals and are also frequently used as probiotics, i.e. bacteria which possibly have health promoting effects when ingested. In this thesis, the intestinal Lactobacillus microbiota was ...
Unexpected salivary secretory effects of some atypical antipsychotics - preclinical studies on clozapine, N-desmethylclozapine, amisulpride and olanzapine
(2013-04-29)
Antipsychotics are generally associated with dry mouth and deterioration of the oral health. However, clozapine, the archetype of the atypical antipsychotics, is reported to induce not only mouth dryness but also, in about ...
Epidemiology of cutaneous malignant melanoma in Western Sweden
(2016-11-23)
The incidence of cutaneous malignant melanoma (melanoma) has been rising worldwide for the
past decades, causing a major public health problem. The overall aim for this thesis was to study the
epidemiology of melanoma ...
Long-term effects of growth hormone replacement in hypopituitary adults on body composition, bone mass and cardiovascular risk factors
(2012-11-06)
Growth hormone (GH) deficient (GHD) adults have decreased bone mass and muscle strength, impaired body composition, disturbed serum lipid pattern and increased morbidity and mortality in cardiovascular and cerebrovascular ...
Identification of stem cell factors - Novel protein-protein interactions and their functions
(2010-09-10)
Embryonic stem (ES) cells provide an unlimited source of cells potentially useful for regenerative medicine, however, prior to clinical implementation, additional basic research is needed. This thesis is focused upon ...
Regulation of vascular endothelial t-PA expression in inflammation: Potential target for pharmacological modulation
(2011-11-03)
The endogenous fibrinolytic system is important for preventing occluding thrombosis and subsequent tissue infarction. The main activator of the fibrinolytic system in the vascular compartment is tissue-type plasminogen ...