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Mechanisms for and consequences of cellular lipid accumulation - Role of the Very Low Density Lipoprotein (VLDL) receptor

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Title: Mechanisms for and consequences of cellular lipid accumulation - Role of the Very Low Density Lipoprotein (VLDL) receptor
Authors: Perman, Jeanna
Issue Date: 2-Dec-2011
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Molecular and Clinical Medicine
Parts of work: I. The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction. Perman JC, Boström P, Lindbom M, Lidberg U, Ståhlman M, Hägg D, Lindskog H, Scharin Täng M, Omerovic E, Mattsson Hultén L, Jeppsson A, Petursson P, Herlitz J, Olivecrona G, Strickland DK, Ekroos K, Olofsson SO, Borén J. infarction.

II. Hypoxia-induced regulation of the very low density lipoprotein receptor Jeanna C. Perman, Ulf Lidberg, Ali Moussavi Nik, Peter Carlsson, Sven-Olof Olofsson and Jan Borén. Manuscript

III. Increased expression of the very low-density lipoprotein receptor mediates lipid accumulation in clear-cell renal cell carcinoma Jeanna C. Perman, Marcus Ståhlman, Max Levin, Sven-Olof Olofsson, Martin E. Johansson and Jan Borén. Manuscript
Date of Defence: 2011-12-15
Disputation: 9:00 Hjärtat, Blå Stråket 5
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: very low density lipoprotein receptor
lipid accumulation
Abstract: Lipid accumulation in non adipose tissue is associated with various cases of tissue dysfunction and tissue failure. Reduced availability of oxygen is known to cause intracellular lipid accumulation in cardiomyocytes as well as in hearts. Cardiac lipid accumulation has been shown to cause impaired cardiac function but it is not fully clear how the lipids accumulate in the hypoxic myocardium. We have studied a model of hypoxic/ischemic myocardium using HL-1 cardiomyocytes incubated in hypoxic con... more
ISBN: 978-91-628-8356-0
Appears in Collections:Doctoral Theses / Doktorsavhandlingar Institutionen för medicin
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses from Sahlgrenska Academy



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