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Radiological and Clinical Changes in Idiopathic Normal Pressure Hydrocephalus: MRI, Vascular factors and Clinical Symptoms as Markers of Pathophysiology and Prognosis
(2020-01-15)
Idiopathic normal pressure hydrocephalus (iNPH) is a treatable, neurological disorder affecting the elderly population causing gait, balance, cognitive and micturition impairments. Treatment results in a clinical improvement ...
Cerebrospinal fluid biomarkers and cognition in older adults
(2021-04-21)
Alzheimer’s disease (AD) is the most common type of dementia. The cause of the disease is unknown, but a substantial amount of evidence suggest that the disease is started by an imbalance in the production and clearance ...
Community onset sepsis in Sweden - a population based study
(2017-11-17)
Sepsis and previously “severe sepsis” are concepts used for denoting organ dysfunction caused by acute infection. Organ dysfunction correlates to increased case fatality rates. Sepsis is a common cause of hospitalization. ...
Environmental exposure to fine particles in Gothenburg - personal exposure and its variability, indoor and outdoor levels, and effects on biomarkers
(2013-03-25)
Urban particulate air pollution has been associated with adverse health effects in epidemiological as well as experimental studies. The overall aim of this thesis was to characterize environmental exposure to fine particles ...
Varicella-zoster virus infections of the central nervous system
(2013-05-24)
Both varicella (chickenpox), and the reactivated form of herpes zoster (shingles), may cause neurological complications with various central nervous system (CNS) manifestations. Following introduction of PCR as a diagnostic ...
Cerebrospinal fluid biomarkers for differentiating between Alzheimer’s disease and Vascular dementia
(2011-05-27)
Patients suffering from mild cognitive impairment (MCI) run a higher risk of developing dementia, with Alzheimer’s disease (AD) being the most common form. Vascular dementia (VaD) is proposed to be the second most common ...
Pituitary Tumor Surgery - factors influencing outcome
(2021-05-05)
Background: Pituitary tumors represent 15–20% of intracranial tumors. The majority are
benign adenomas, of which 30 % are hormonally inactive, the non-functioning pituitary
adenomas (NFPAs). A possible neuronal damage ...
Biomonitoring of Cadmium - Relationship between Cadmium in Kidney, Blood and Urine, Interpretation of Urinary Cadmium, and Implications for Study Design
(2014-04-04)
Cadmium is an environmental contaminant which accumulates in the
kidney and can potentially affect human health at relatively low
concentrations. Biomarkers such as cadmium in urine or blood are
normally used to assess ...
Long-term radiobiological effects of 131I exposure - dose, age and time related transcriptomatic and proteomic rasponse in rats
(2021-03-23)
131I is commonly used in the clinic for treating thyroid diseases, using the physiological uptake of iodine in thyroid, but also for other target tissues. 131I is also commonly released during nuclear accidents. Children ...
Alphaherpesvirus infections of the central nervous system – Biomarkers, diagnostics and antiviral therapy
(2021-05-25)
Abstract
Herpesviruses predate the evolution of humans and are globally ubiquitous. Herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and varicella-zoster virus (VZV) establish latency in neuronal ...