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Biomonitoring of Cadmium - Relationship between Cadmium in Kidney, Blood and Urine, Interpretation of Urinary Cadmium, and Implications for Study Design


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Title: Biomonitoring of Cadmium - Relationship between Cadmium in Kidney, Blood and Urine, Interpretation of Urinary Cadmium, and Implications for Study Design
Authors: Åkerström, Magnus
E-mail: magnus.akerstrom@amm.gu.se
Issue Date: 4-Apr-2014
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Public Health and Community Medicine
Parts of work: I. Akerstrom M, Barregard L, Lundh T, Sallsten G. The relationship between cadmium in kidney and cadmium in urine and blood in an environmentally exposed population. Toxicology and Applied Pharmacology. 2013 May 1;268(3):286-93
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II. Akerstrom M, Sallsten G, Lundh T, Barregard L. Associations between Urinary Excretion of Cadmium and Proteins in a Nonsmoking Population: Renal Toxicity or Normal Physiology? Environmental Health Perspectives. 2013 Feb;121(2):187-91.
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III. Akerstrom M, Lundh T, Barregard L, Sallsten G. Effect of molybdenum oxide interference on urinary cadmium analyses. International Archives of Occupational and Environmental Health. 2013 Jul;86(5):615-7
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IV. Akerstrom M, Barregard L, Lundh T, Sallsten G. Variability of urinary cadmium excretion in spot urine samples, first morning voids, and 24 h urine in a healthy non-smoking population: Implications for study design. Journal of Exposure Science and Environmental Epidemiology. 2014 Mar;24(2):171-9
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Date of Defence: 2014-04-25
Disputation: Fredagen den 25 april 2014, kl 9:00, Salen Hamberger, Medicinaregatan 16
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: cadmium
urine
blood
kidney
biological half-time
variability
biomarkers
determinants
study design
Abstract: Cadmium is an environmental contaminant which accumulates in the kidney and can potentially affect human health at relatively low concentrations. Biomarkers such as cadmium in urine or blood are normally used to assess the body burden of cadmium. We studied the relationship between cadmium in urine, blood, and kidney by using 109 healthy environmentally exposed kidney donors. The variability in urinary cadmium excretion, its interpretation, and effects on the study design were further exa... more
ISBN: 978-91-628-8923-4 (printed)
978-91-628-9872-2 (e-pub)
URI: http://hdl.handle.net/2077/34823
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin

 

 

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