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Heart Failure and Aortic Stenosis - Factors Influencing Prognosis and Development
(2021-04-27)
Background: An ageing population increases the prevalence of heart failure (HF) and aortic stenosis (AS). Several studies have investigated prognosis and predictors of HF with preserved ejection fraction (HFpEF) compared ...
Genes, lifestyle and coronary heart disease risk-epidemiological interaction studies
(2015-03-03)
Coronary heart disease (CHD) has multifactorial background involving both genetic and lifestyle factors, but much is still unknown about their interactions. The aim of this thesis was to study interactions focusing on ...
Weight loss studies in obese patients. Aspects of very-low-energy diet treatment and effects of obesity surgery on disability pension
(2010-03-02)
Obesity is associated with increased risk of serious medical conditions, impaired quality of life, reduced working capacity, and shortened life expectancy. Obesity surgery is the most effective weight loss treatment with ...
IL-6 and GLP-1 in body fat regulating parts of the CNS in healthy mice
(2016-01-29)
It has previously been shown that mice lacking interleukin-6 (IL-6) develop mature onset obesity. The weight-suppressing effects of IL-6 have been assumed to be exerted at a central level, as supported by the fact that ...
Adiponectin, the metabolic syndrome and atherosclerosis. Observation and intervention studies
(2006)
Adiponectin (Adn) has beneficial effects on insulin- and glucose metabolism as well as anti-inflammatory properties. High Adn concentrations are associated with reduced risks for insulin resistance and future diabetes, and ...
Regulation of IL-6-signaling and inflammatory response – Role of insulin, FOXO1 and PKCδ
(2010-04-27)
The aim of this thesis was to investigate if and how insulin antagonizes interleukin-6 (IL-6)-signaling and
action using both 3T3-L1 mouse adipocytes (Paper I) and HepG2 human hepatocytes (Paper III). We also
investigated ...
Urethral strictures in men: Studies on reconstructive surgery and pathophysiology
(2016-11-14)
Urethral stricture is a common disease that is characterised by fibrotic tissue arising from inflammation after urethral injury. Urination is inhibited when there is total obstruction, and the suffering is immense. Following ...
Bone and fat tissue in children and adolescents: studies with focus on osteocalcin
(2016-09-15)
The general AIM was to investigate the possible interplay between bone and
fat tissue through clinical studies of children and adolescents. Osteocalcin
(OC), a bone formation marker, has been proposed to act as a link ...
Aspects of Plasminiogen Activator Inhibitor 1 in Metabolic Syndrome
(2016-05-31)
Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of the fibrinolytic system
and binds irreversibly to tissue-type plasminogen activator (t-PA), and thereby inhibits the protective action of t-PA against ...