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Genes, lifestyle and coronary heart disease risk-epidemiological interaction studies


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Title: Genes, lifestyle and coronary heart disease risk-epidemiological interaction studies
Authors: Gustavsson, Jaana
E-mail: jaana.gustavsson@amm.gu.se
Issue Date: 3-Mar-2015
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Medicine. Department of Public Health and Community Medicine
Parts of work: I. Gustavsson J, Mehlig K, Leander K, Strandhagen E, Björck L, Thelle DS, et al. Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women. Atherosclerosis 2012;220:486-492
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II. Gustavsson J, Mehlig K, Leander K, Lissner L, Björck L, Rosengren A et al. FTO genotype, physical activity and coronary heart disease risk in Swedish men and women. Circ Cardiovasc Gen 2014;7:171-177
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III. Gustavsson J, Mehlig K, Leander K, Berg C, Tognon G, Strandhagen E et al. FTO gene variation, marconutrent intake and coronary heart disease risk: a gene-diet interaction analysis. Eur J Nutr
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IV. Jaana Gustavsson, Kirsten Mehlig, Elisabeth Strandhagen, Karin Leander, Kaj Blennow, Henrik Zetterberg, Annika Rosengren, Dag S. Thelle, Fredrik Nyberg, Lauren Lissner. FTO and GHRL gene-gene interaction on body mass index. Submitted manuscript
Date of Defence: 2015-03-27
Disputation: Fredagen den 27 mars 2015, kl. 9.00, Hörsal Arvid Carlsson, Academicum, Medicinaregatan 3
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: Coronary heart disease
gene-lifestyle interaction
APOE
FTO
GHRL
smoking
physical activity
diet
obesity
Abstract: Coronary heart disease (CHD) has multifactorial background involving both genetic and lifestyle factors, but much is still unknown about their interactions. The aim of this thesis was to study interactions focusing on apolipoprotein E (APOE), fat mass and obesity-related (FTO) and ghrelin/obestatin prepropeptide (GHRL) genes, as well as smoking, physical activity and diet. The study sample included 1831 cases with CHD (myocardial infarction or unstable angina) and 5175 population controls from t... more
ISBN: ISBN (printed): 978-91-628-9344-6
ISBN (e-publ): 978-91-628-9345-3
URI: http://hdl.handle.net/2077/37999
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för medicin

 

 

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