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Citrobacter rodentium and Escherichia coli interactions with mucus producing colonic epithelical cells
(2019-11-06)
The epithelial cells together with the mucus layer protect the host from noxious luminal substances and pathogenic invasion. Pathogens have evolved numerous strategies to circumvent these barriers and mount infection. C. ...
On Complications to Cataract Surgery
(2015-04-08)
Cataract surgery, meaning exchange of the opaque lens in the eye with an artificial lens, is nowadays one of the most successful surgical procedures ever known. It is also the most frequent surgery performed in the Western ...
Regulatory T cells and mucosal-associated invariant T cells in colon adenocarcinomas; Phenotype and function
(2019-02-27)
In many solid cancers, and also in colon adenocarcinomas, an increased accumulation of lymphocytes is beneficial for the patient. However, tumor-infiltrating immune cells may be either pro- or anti-tumorigenic and the ...
Modulation of Inflammatory Response in Surgical Trauma
(2012-09-12)
Surgical trauma results in the activation of inflammatory cascade systems in the body. Excessive systemic inflammation can lead to organ dysfunction in one or several organs. The thesis aims to describe the body's inflammatory ...
On the pathogenesis of infections associated with percutaneous osseointegrated orthopaedic implants
(2018-11-22)
Orthopaedic implants enable the restitution of locomotor function and improve the quality of life of many people. However, biomaterial-associated infection may occur due to the propensity of microorganisms to adhere and ...
The Role of the Autonomic Nervous System in Atherosclerosis - Targeting the Cholinergic Anti-inflammatory Pathway in Humans and Mice
(2017-01-20)
The autonomic nervous system (ANS) has been implicated in numerous atherosclerosis-induced cardiovascular disease, such as myocardial infarction and stroke. Although evidence suggests a relationship between autonomic ...
Pediatric Autoinflammatory Diseases: Conceptual, Clinical, and Mechanistic Dimensions
(2015-09-10)
This thesis focuses on three paediatric autoinflammatory diseases in Sweden today; familial Mediterranean fever (FMF), periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) and synovitis, acne, ...
Molecular and structural patterns of guided bone regeneration (GBR). Experimental studies on the role of GBR membrane and bone substitute materials
(2015-09-15)
The mechanisms of guided bone regeneration (GBR) and bone healing with calcium phosphate (CaP) bone substitutes are not fully understood. The major aim of this thesis was to determine the relationship between the bone ...
Inflammatory responses in minor and major surgical procedures
(2010-05-12)
Surgical procedures promote an inflammatory response, correlating to the extent of the procedure performed and influencing outcome after surgery. The aims of the thesis were to investigate factors modulating the inflammatory ...
Inflammatory mediator response to Gram-positive and Gram-negative bacteria in vitro and in middle ear infections
(2010-02-12)
Based on the structure of the cell wall, bacteria are divided into Gram-positive and Gram-negative. While the cell wall of Gram-positive bacteria is thick, the cell wall of Gram-negatives is very thin and surrounded by an ...