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Cognitive dysfunction studied in animal models of schizophrenia
(2006-12-01)
Cognitive dysfunction is considered a core deficit of schizophrenia, which currently lacks effective pharmacological treatment. In order to identify novel and more effective drug treatments, translational experimental ...
Differential effects of voluntary running on hippocampal plasticity in the adult rat brain
(2005)
The continuation of neuronal birth from dividing neural stem cells in the dentate gyrus of the hippocampus throughout adulthood is known to play an important role in maintaining normal hippocampal function, such as memory ...
Neurogenesis and gliogenesis after focal brain ischemia. Modulation by enriched environment and exercise
(2005)
New neurons are formed from dividing neural stem cells in restricted areas in the adult mammalian brain: the dentate gyrus of the hippocampal formation (DG) and the forebrain subventricular zone (SVZ). New glia also form ...
Microdosimetry of radiohalogens in thyroid models
(2014-02-10)
The radiohalogens 123I, 124I, 125I, 131I, and 211At are routinely used or proposed for diagnostic and therapeutic purposes. The different characteristics and application areas of these radioiodine isotopes, together with ...
Uterus transplantation: an experimental study in the rat model
(2012-12-04)
One of the last frontiers to conquer in infertility research is to find a treatment for uterine factor infertility, which
affects around 2500 Swedish women. These women cannot become pregnant or carry a pregnancy due ...
Mechanisms of Osseointegration: Experimental Studies on Early Cellular and Molecular Events in vivo
(2010-06-14)
The early cellular and molecular activities determining the early tissue response and bone formation at bone/implant interface are not fully understood. The general aim of the current thesis was to develop a model for ...
Effects of 5-fluorouracil on oral barrier functions
(2002)
Many anticancer drugs, e.g. 5-fluorouracil (5-FU), may cause oral mucositis andulcerations. These adverse reactions can be severe and debilitating to the patient, andadjustment of the cancer treatment may be necessary. ...
Pathophysiological importance of Beta1-Adrenergic receptor autoantibodies in the development of cardiomyopathy and heart failure. Clinically and experimentally
(2006)
Idiopathic Dilated Cardiomyopathy (DCM) is a heart muscle disease of unknown originthat is characterized by ventricular dilation and the impaired contraction of the left orboth ventricles, resulting in progressive heart ...
Sensory and secretory responses to intestinal distension; implications for the pathophysiology of the irritable bowel syndrome
(2007-06-18)
Irritable bowel syndrome (IBS) is a common gut disorder, characterized by abdominal pain and/or discomfort associated with disturbed bowel habits. The pathophysiology of IBS is complex and still largely unknown, although ...
Brain Regeneration - in vitro and in vivo studies of exercise-related effects on brain plasticity
(2008-06-13)
Neural stem and progenitor cells in the germinal regions of the adult brain, such as the hippocampus, are of great interest, because they provide the possibility for enhanced brain plasticity or can contribute to endogenous ...