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Uterus transplantation: an experimental study in the rat model


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Title: Uterus transplantation: an experimental study in the rat model
Authors: Akhi, Musammad Shamima Nazmin
E-mail: shamima.akhi@obgyn.gu.se
Issue Date: 4-Dec-2012
University: University of Gothenburg. Sahlgrenska Academy
Institution: Institute of Clincial Sciences. Department of Obstetrics and Gynecology
Parts of work: I. Uterus transplantation in the rat: model development, surgical learning and morphological evaluation of healing. Wranning CA, Akhi SN, Kurlberg G, Brännström M.
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II. Pregnancy after syngeneic uterus transplantation and spontaneous mating in the rat. Wranning CA, Akhi SN, Díaz-García C, Brännström M.
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III. Uterine rejection after allogeneic uterus transplantation in the rat is effectively suppressed by tacrolimus. Akhi SN, Díaz-García C, El-Akouri RR, Wranning CA, Mölne J, Brännström M. Fertil Steril 2013; in press.

IV. Monitoring rejection after uterus transplantation: morphological assessment of different sites of a uterine allograft in a rat model. Akhi SN, Díaz-García C, El-Akouri RR, Brännström M, Mölne J. Unpublished manuscript.

V. First report on fertility after allogeneic uterus transplantation. Díaz-García C, Akhi SN, Wallin A, Pellicer A, Brännström M.
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VI. Live offspring after allogeneic uterus transplantation in the rat. Akhi SN, Díaz-García C, Brännström M. Unpublished manuscript.
Date of Defence: 2012-12-21
Disputation: Fredagen den 21 december 2012, kl 9.00, Stammens föreläsningssal, Kvinnokliniken, Sahlgrenska Universitetssjukhuset, Göteborg
Degree: Doctor of Philosophy (Medicine)
Publication type: Doctoral thesis
Keywords: infertility
microsurgery
pregnancy
rat
transplantation
uterus
Abstract: One of the last frontiers to conquer in infertility research is to find a treatment for uterine factor infertility, which affects around 2500 Swedish women. These women cannot become pregnant or carry a pregnancy due to absence of uterus or presence of non-functioning uterus. During recent years, several animal models have been used in research to develop uterus transplantation into a clinical treatment for uterine factor infertility. In the present study, the rat was used as a uterus transp... more
ISBN: 978-91-628-8595-3
URI: http://hdl.handle.net/2077/30561
Appears in Collections:Doctoral Theses from Sahlgrenska Academy
Doctoral Theses from University of Gothenburg / Doktorsavhandlingar från Göteborgs universitet
Doctoral Theses / Doktorsavhandlingar Institutionen för kliniska vetenskaper

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